正常高值血压肝火亢盛证与血浆同型半胱氨酸的相关性研究  

Correlation Study Between Prehypertensive Liver-Fire Hyperactivity Syndrome and Plasma Homocysteine

作　　者：杨洁[1] 胡芳晓 杨传华[1] YANG-Jie;HU Fang-xiao;YANG Chuan-hua(Department of Cardiology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan Shandong 250011;First clinical medical college,Shandong University of Traditional Chinese Medicine,Jinan Shandong 250011)

机构地区：[1]山东中医药大学附属医院心病一科,山东济南250011 [2]山东中医药大学第一临床医学院,山东济南250011

出　　处：《世界中西医结合杂志》2024年第8期1592-1597,1602,共7页World Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金面上项目(82374385);泰山学者青年专家岗位建设资金资助项目(tsqn202211352);山东省中医药管理局项目(M-2023058)

摘　　要：目的探讨正常高值血压肝火亢盛证与同型半胱氨酸相关性及其化验指标的关系。方法选取2016年11月—2019年11月期间山东中医药大学附属医院心病科就诊及体检人群正常高值血压肝火亢盛证患者84例,同时选取同期就诊的理想血压人群53例、高血压肝火亢盛证人群52例,受试者进行一般检查(身高、体质量、血压、静息心率),血浆同型半胱氨酸(Homocysteine,Hcy)、生化指标、尿微量白蛋白检测。结果正常高值血压肝火亢盛证组中血清高同型半胱氨酸(Hyper homocysteine,HHcy)检出率为7.14%,高血压肝火亢盛证组中血清高同型半胱氨酸检出率为76.92%,呈递增趋势。正常高值血压肝火亢盛证组尿微量白蛋白阳性检出率为1.92%,高血压肝火亢盛证组尿微量白蛋白阳性检出率为10.81%,呈递增趋势。LSD-t检验结果可知Hcy在正常血压组与高血压肝火亢盛证组及正常高值血压肝火亢盛证组与高血压肝火亢盛证组之间,差别有统计学意义(P<0.05);总胆固醇在正常血压与正常高值血压之间,差别有统计学意义(P<0.05);低密度脂蛋白胆固醇(Low-density lipoprotein cholesterol,LDL-C)在正常血压与正常高值血压之间,差别有统计学意义(P<0.05)。对正常高值血压肝火亢盛证组同型半胱氨酸值行pearson相关分析,结果显示,同型半胱氨酸与血清尿酸、血清肌酐具有相关性(P<0.05)。结论在正常高值血压肝火亢盛证人群中同型半胱氨酸升高,且同型半胱氨酸与血清尿酸、血清肌酐具有相关性。Objective To investigate the correlation between prehypertensive liver-fire hyperactivity syndrome and homocysteine and its assay indexes.Methods From November 2016 to November 2019,84 patients diagnosed with prehypertensive liver-fire hyperactivity syndrome were selected from the Department of Cardiology and Health Examination Center at the Affiliated Hospital of Shandong University of Traditional Chinese Medicine.Meanwhile,53 patients with ideal blood pressure and 52 patients with hypertensive liver-fire hyperactivity syndrome were treated during the same period.Subjects underwent general examinations(height,weight,blood pressure,resting heart rate),and tests for plasma homocysteine(Hcy),biochemical indicators,and urinary microalbumin levels.Results The detection rate of serum hyperhomocysteine(HHcy)in the prehypertensive liver-fire hyperactivity syndrome group was 7.14%,while the detection rate of HHcy in the hypertensive liver-fire hyperactivity syndrome group was 76.92%,showing an increasing trend.The positive detection rate of urinary microalbumin in the prehypertensive liver-fire hyperactivity syndrome group was 1.92%and 10.81%in the hypertensive liver-fire hyperactivity syndrome group,showing an increasing trend.LSD-t test results showed statistically significant differences in Hcy levels between the ideal blood pressure group and both the hypertensive liver-fire hyperactivity syndrome group and the prehypertensive liver-fire hyperactivity syndrome group,with a statistically significant difference(P<0.05).There were also significant differences in total cholesterol and low-density lipoprotein cholesterol(LDL-C)levels between the ideal blood pressure group and the prehypertensive liver-fire hyperactivity syndrome group,with a statistically significant difference(P<0.05).Pearson correlation analysis of homocysteine levels in the prehypertensive liver-fire hyperactivity syndrome group showed that homocysteine correlated with serum uric acid and serum creatinine(P<0.05).Conclusion Homocysteine levels are elev

关 键 词：正常高值血压 肝火亢盛证 同型半胱氨酸 

分 类 号：R544.1[医药卫生—心血管疾病]