健脾升清利咽汤治疗脾胃虚弱型慢性咽炎患者的临床疗效及对其生活质量的影响  

Clinical Efficacy of Jianpi Shengqing Liyan Decoction in Treating Chronic Pharyngitis of the Spleen and Stomach Weakness Type and Its Impact on Quality of Life

作　　者：魏然[1] 姜辉[1] 王嘉玺[1] 李金飞[1] WEI Ran;JIANG Hui;WANG Jia-xi;LI Jin-fei(Department of Otolaryngology,Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078)

机构地区：[1]北京中医药大学东方医院耳鼻喉科,北京100078

出　　处：《世界中西医结合杂志》2024年第8期1647-1650,1656,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：全国第七批名老中医师承项目(040103005002018);2018国家重点研发计划:基于“道术结合”与多元融合方法的名老中医经验传承创新研究(2018YFC1704100);名老中医经验挖掘与传承的方法学体系和范式研究(2018YFC1704101)。

摘　　要：目的观察名中医刘大新教授采用健脾升清利咽汤治疗脾胃虚弱型慢性咽炎患者的疗效及对其生活质量的影响。方法选取2019年10月—2021年12月期间于北京中医药大学东方医院刘大新教授门诊就诊的脾胃虚弱型慢性咽炎患者80例,采用随机数字表法分为对照组和治疗组,每组各40例。对照组选用四君子汤治疗,治疗组则采用健脾升清利咽汤。治疗14 d后,观察比较两组患者临床疗效、不良反应情况,治疗前后临床症状、体征及生活质量评分。结果治疗后治疗组临床总有效率90.00%(36/40)明显高于对照组60.00%(24/40),差异有统计学意义(P<0.05)。治疗7、14 d后两组患者咽干、咽痛、次要症状(咽异物感、咽痒、咳嗽、咯痰)、咽后壁黏膜、咽后壁淋巴滤泡增生及咽侧索粗厚评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组临床症状、体征评分均明显低于对照组同期,差异有统计学意义(P<0.05)。治疗7、14 d后两组患者生活质量量表PF、RP、BP、GH、VT、SF、MH、RE评分均较治疗前升高,差异有统计学意义(P<0.05);且治疗组生活质量量表(SF-36)评分明显高于对照组同期,差异有统计学意义(P<0.05)。治疗期间,两组患者均无不良事件发生。结论健脾升清利咽汤治疗脾胃虚弱型慢性咽炎能有效提高临床疗效,改善患者生活质量。Objective To observe the clinical efficacy of Master TCM physician Liu Daxin's Jianpi Shengqing Liyan decoction in treating chronic pharyngitis patients with spleen and stomach weakness and its impact on their quality of life.Methods A total of 80 patients with chronic pharyngitis characterized by spleen and stomach weakness,who visited Professor Liu Daxin's outpatient clinic at the Oriental Hospital of Beijing University of Chinese Medicine between October 2019 and December 2021,were selected as the research object.They were divided into a control group and a treatment group according to the random number table method,with 40 patients in each group.The control group received Sijunzi decoction,while the treatment group received Jianpi Shengqing Liyan decoction.After 14 days of treatment,clinical efficacy,adverse reactions,clinical symptoms,signs,and quality of life scores before and after treatment were observed and compared between the two groups.Results After treatment,the total clinical effective rate in the treatment group was 90%(36/40),significantly higher than the 60%(24/40)in the control group,with a statistically significant difference(P<0.05).At 7 and 14 days post-treatment,scores for throat dryness,throat pain,secondary symptoms(foreign body sensation in the throat,throat itching,cough,sputum production),posterior pharyngeal wall mucosa,lymphoid follicular hyperplasia,and thickening of the posterior pharyngeal wall were significantly reduced in both groups compared to pre-treatment levels,with a statistically significant difference(P<0.05).Moreover,the symptom and sign scores in the treatment group were significantly lower than those in the control group during the same period,with statistically significant differences(P<0.05).At 7 and 14 days after treatment,the quality of life scores for PF,RP,BP,GH,VT,SF,MH,and RE in both groups significantly improved compared to pre-treatment scores,with statistically significant differences(P<0.05).The SF-36 quality of life scores in the treatment group were signi

关 键 词：刘大新 健脾升清利咽汤 脾胃虚弱 慢性咽炎 生活质量 

分 类 号：R766.14[医药卫生—耳鼻咽喉科]