HLA-G14bp插入/缺失多态性与1型糖尿病的相关性研究  

The Association Between the HLA-G14bp Insertion/Deletion Polymorphism and Type 1 Diabetes

作　　者：章康威 谢玉霜 付晓俐 潘欣怡 吴志农 单士刚[3] 包永芬[4,5] ZHANG Kang-wei;XIE Yu-shuang;BAO Yong-fen(School of Pharmacy,Xianning Medical College,Hubei University of Science and Technology,Xianning Hubei 437100,China)

机构地区：[1]湖北科技学院医学部药学院,湖北咸宁437100 [2]咸宁市中心医院/湖北科技学院附属第一医院 [3]湖北科技学院医学部公共卫生与健康学院 [4]湖北科技学院医学部基础医学院 [5]湖北科技学院糖尿病心脑血管病变湖北省重点实验室

出　　处：《湖北科技学院学报（医学版）》2024年第5期405-408,共4页Journal of Hubei University of Science and Technology(Medical Sciences)

基　　金：湖北科技学院糖尿病专项(2016-18XZ11);湖北省大学生创新创业训练计划项目(201610927014,201810927004)。

摘　　要：目的探讨湖北汉族糖尿病患者HLA-G14bp插入/缺失多态性与1型糖尿病易感性的相关性。方法采用聚合酶链反应-序列特异引物(PCR-SSP)方法,对湖北地区70例汉族1型糖尿病患者和100例正常对照者进行HLA-G14bp基因的插入/缺失位点检测,并对各基因型与临床症状的相关性进行分析。结果HLA-G14bp插入/缺失多态性在健康者和1型糖尿病患者均显示Hardy-Weinberg平衡;1型糖尿病患者与健康对照组比较,HLA-G14bp+/+、+/-及-/-基因型存在显著性差异(P<0.05);HLA-G14bp的插入/缺失位点在不同的病程中无显著性差异(P>0.05)。结论在湖北地区汉族人群中,HLA-G14bp插入/缺失多态性可能与1型糖尿病疾病易感性相关。Objective To explore the association of HLA-G14bp insertion/deletion diversity with the susceptibility of type 1 diabetes mellitus and other clinical features in Han Chinese diabetic patients in Hubei.Methods HLA-G14bp insertion/deletion polymorphisms were detected in 70 Han Chinese patients with diabetes mellitus and 100 unrelated healthy patients in Hubei Province by PCR(PCR-SSP),and the relationship between the relevant clinical features and different genotypes was analysed.Results HLA-G14bp insertion/deletion polymorphisms showed Hardy-Weinberg equilibrium in both type 1 diabetic patients and unrelated healthy individuals,and the HLA-G14bp+/+,+/-and-/-genotypes were significantly different in the diabetic group compared with the healthy control group(P<0.05).There was no statistically significant difference in HLA-G14bp insertion/deletion polymorphisms between case groups of diabetic patients in different disease courses(P>0.05).Conclusion HLA-G14bp insertion/deletion polymorphisms may be associated with the occurrence of type 1 diabetes disease susceptibility in the Han Chinese population in Hubei Province.

关 键 词：1型糖尿病 HLA-G14bp 插入/缺失 多态性 

分 类 号：R587.1[医药卫生—内分泌]