贝那普利联合艾司洛尔对合并快速心律失常的感染性休克患者心肌酶谱水平的影响  

Effects of Benapril Combined with Esmolol on the Myocardial Enzyme Spectrum Levels in Patients with Infectious Shock Combined with Rapid Arrhythmias

作　　者：刘立新 童绥菊 LIU Li-xin;TONG Sui-ju(Department of Emergency Medicine,Wuhan Dongxihu District People's Hospital,Wuhan Hubei 430040,China)

机构地区：[1]武汉市东西湖区人民医院急诊医学科,湖北武汉430040 [2]武汉市东西湖区人民医院药剂科

出　　处：《湖北科技学院学报（医学版）》2024年第5期418-421,共4页Journal of Hubei University of Science and Technology(Medical Sciences)

摘　　要：目的分析贝那普利联合艾司洛尔对合并快速心律失常的感染性休克患者心肌酶谱水平的影响。方法选取我院收治的合并快速心律失常感染性休克患者90例,随机分为对照组、观察组,每组各45例。对照组给予贝那普利治疗,观察组在对照组的基础上给予艾司洛尔注射治疗,观察并对比两组心肌损害一般标志物、心肌酶谱、心功能指标、炎症因子和临床疗效水平。结果治疗后,观察组心肌肌钙蛋白-I(cTn-I)、B型脑钠肽(BNP)下降、血清白蛋白(PA)升高更显著,血清乳酸脱氢酶1(LDH1)、肌酸激酶(CK)、α-羟丁酸脱氢酶(α-HBDH)、肌酸激酶同工酶(CK-MB)降低更显著,具有统计学差异(P均<0.05);观察组心输出量(CO)、左心室舒张早期/晚期速度峰值比值(VA/VE)、超敏C-反应蛋白(hs-CRP)、白细胞介素(IL-6)、肿瘤坏死因子α(TNF-α)水平降低,心搏量(SV)、射血分数(EF)升高更显著,且治疗总有效率高于对照组,具有统计学差异(P均<0.05)。结论贝那普利联合艾司洛尔会降低合并快速心律失常感染性休克患者心肌酶谱水平,减少血小板激活所生成的缩血管物质及炎性物质,抑制炎症反应,改善内皮细胞功能,临床疗效显著。Objective To analyze the effect of Benapril combined with Esmolol on myocardial enzyme spectrum levels in patients with infectious shock combined with rapid arrhythmias.Methods 90 patients with infection shock complicated with rapid arrhythmia admitted to our hospital were randomly divided into a control and an observation group,with 45 patients in each group.The control group was treated with benazepril,and the observation group was given esmolol injection on the basis of the control group.The general markers of myocardial damage,myocardial enzyme spectrum,cardiac function indexes,inflammatory factors and clinical efficacy levels of the two groups were observed.Results After the treatment,the levels of myocardial calponin-I(cTn-I),type B brain naturetic peptide(BNP)decreased,and serum albumin(PA)increased more significantly,and serum lactate dehydrogenase 1(LDH1),creatine kinase(CK),beta-hydrobutyrate dehydrogenase(α-HBDH),and creatine kinase isoenzyme(CK-MB)decreased more significantly in the observation group,with statistical differences(all P<0.05).Cardiac output(CO),left ventricular diastolic early/late peak velocity ratio(VA/VE),hypersensitivity C-reactive protein(hs-CRP),interleukin(IL-6),tumor necrosis factorα(TNF-α),increased pacing volume(SV),ejection fraction(EF),decreased in the observation group,and stroke volume(SV)and ejection fraction(EF)increased more significantly,and the total effective rate of treatment was higher than that in the control group,with statistical differences(all P<0.05).Conclusion Benapril combined with esmololcan reduce the myocardial enzyme spectrum level in patients with infection shock complicated with rapid arrhythmia,reduce vasoconstrictor and inflammatory substances generated by platelet activation,inhibit inflammatory response,improve endothelial cell function,and have significant clinical efficacy.

关 键 词：快速心律失常 感染性休克 心肌酶谱 心功能 肌酸激酶 

分 类 号：R541.7[医药卫生—心血管疾病]