“适应原-补益”样作用:应变稳态超负荷调节中的新概念  

A new concept on regulation of allostatic overload:“Adaptogens-tonics”effect

作　　者：王格瑩 宫贺 傅必如 郭碧钰 刘昌孝 何新[1] WANG Geying;GONG He;FU Biru;GUO Biyu;LIU Changxiao;HE Xin(Guangdong Pharmaceutical University,Guangzhou 510006,China;Tianjin Institute of Pharmaceutical Research,Tianjin 300462,China)

机构地区：[1]广东药科大学,广东广州510006 [2]天津药物研究院,天津300462

出　　处：《中草药》2024年第16期5371-5385,共15页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82174209)。

摘　　要：正常人体保持在一个相对稳定的状态,当机体受到内外界因素干扰时,稳态失衡,阴阳失调,人体系统紊乱,则可能导致一系列疾病的产生。在应变稳态的过程中,适应原类植物可帮助机体在应激状态下保持在最佳的平衡状态。现代研究阐明其能够多途径、多靶点作用于机体的神经-免疫-内分泌轴等,并与神经、内分泌、消化、代谢、心血管等系统关联密切。补益药中药多具有适应原样作用,有调节神经-内分泌、增强免疫、促进能量代谢、增强适应性等功能,在此基础上笔者首次提出“适应原-补益”样作用,深入归纳研究此类药物的有效成分及其作用机制,并根据中医药原理分析不同适应原样中药的适用范围,同时用适应原样调节作用分析研究中医药,为进一步研究、开发和利用适应原样中药提供参考,有利于取得理论突破与提高疗效,促进中医药的现代化和国际化。The normal human body remains in a relatively stable state.When the body is disturbed by internal and external factors,the steady-state imbalance,yin-yang imbalance and human system disorder may lead to a series of diseases.In the process of strain homeostasis,adaptogens help the body to maintain an optimal state of balance under stress.Modern studies have shown that it can act on the neuro-immune-endocrine axis of the body in multiple ways and targets,and is closely related to the nervous system,internal secretion,digestion,metabolism,cardiovascular system and other systems.Most of the tonics have the function of adapting to the original,regulating the neuroendocrine,enhancing the prevention of disease,promoting energy metabolism,enhancing the adaptability and so on.On this basis,the author proposed the“adaptogens-tonics”effect for the first time,thoroughly summarized and studied the active ingredients and mechanism of such drugs,and analyzed the application scope of different adapted original traditional Chinese medicines(TCM)according to the principles of TCM.At the same time,the analysis of the adjustment effect of adaptogenic samples of TCM provides a reference for further research,development and utilization of adaptogenic TCM,which is conducive to making theoretical breakthroughs and improving curative effect,and promoting the modernization and internationalization of TCM.

关 键 词：适应原 补益药 “适应原-补益”样作用 应变稳态 应激源 应变稳态超负荷 系统医学 

分 类 号：R285[医药卫生—中药学]