基于“肾脑相济”理论探讨安神补脑液防治阿尔茨海默病  

Prevention and treatment of Alzheimer’s disease by Anshen Bunao Liquid based on“kidney brain integration”theory

作　　者：孙元芳 赖嘉敏 王永宽[4] 王乐琪 严诗楷[1] 刘刚 张秀云[4] 李莎莎 肖雪[3] SUN Yuanfang;LAI Jiamin;WANG Yongkuan;WANG Leqi;YAN Shikai;LIU Gang;ZHANG Xiuyun;LI Shasha;XIAO Xue(School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China;The Second Clinical College of Guangzhou University of Chinese Medicine,Guangzhou 510120,China;Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine(Institute of Traditional Chinese Medicine),Guangdong Pharmaceutical University,Guangzhou 510006,China;Jilin Aodong Yanbian Pharmaceutical Co.,Ltd.,Yanbian 133700,China)

机构地区：[1]上海交通大学药学院,上海200240 [2]广州中医药大学第二附属医院,广东广州510120 [3]广东药科大学广东省代谢病中西医结合研究中心(中医药研究所),广东广州510006 [4]吉林敖东延边药业股份有限公司,吉林延边133700

出　　处：《中草药》2024年第16期5692-5703,共12页Chinese Traditional and Herbal Drugs

基　　金：吉林省科技发展计划项目(20150311115YY);国家中药标准化项目(ZYBZH-C-JL-22);广州市科技计划项目珠江科技新星专项(201610010113)。

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是一种慢性神经系统退行性疾病,以智力障碍和认知功能减退为主要症状。AD病因复杂,目前临床上尚无有效的治疗药物,中医药通过多成分、多靶点和多通路协同作用发挥疗效,对治疗AD具有一定优势。AD在中医学中属“痴呆”等范畴,其核心病机为肾虚髓亏,治疗上应注重肾脑相济、生精补髓。通过基于“肾脑相济”理论探讨安神补脑液防治AD的可行性,为安神补脑液的深度开发、中医药防治AD的研究做出有益探索。Alzheimer’s disease(AD)is a chronic neurodegenerative disease with intellectual impairment and cognitive decline as the main symptoms.The etiology of AD is complex,and there are no effective therapeutic drugs in clinical practice.Traditional Chinese medicine(TCM)has certain advantages in treatment of AD through the synergistic effect of multi-components,multi-targets and multi-pathways.AD belongs to the category of“dementia”in the theoretical system of TCM.Its core pathogenesis is kidney deficiency and marrow deficiency.The treatment should pay attention to the coordination of kidney and brain and the production of essence and marrow.Based on the theory of“kidney brain integration”,the feasibility of Anshen Bunao Liquid(安神补脑液,ABL)in preventing and treating AD was explored,to make a useful exploration for the in-depth development of ABL and the research on preventing and treating AD in TCM.

关 键 词：阿尔茨海默病 安神补脑液 肾脑相济 生精补髓 鹿茸 制何首乌 淫羊藿 甘草 

分 类 号：R285[医药卫生—中药学]