亚精胺生物活性及其开发应用的研究进展  

Research progress of spermidine bioactivity and its development and application

作　　者：任佳丽 於天 高欣晨 陈位三 赵盈 李先宽[1] 於洪建 REN Jiali;YU Tian;GAO Xinchen;CHEN Weisan;ZHAO Ying;LI Xiankuan;YU Hongjian(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Ganli Pharmaceutical Co.,Ltd.,Beijing 101100,China;Hefei Hechen Biotechnology Co.,Ltd.,Hefei 230011,China)

机构地区：[1]天津中医药大学,天津301617 [2]甘李药业股份有限公司,北京101100 [3]合肥和晨生物科技有限公司,安徽合肥230011

出　　处：《中草药》2024年第16期5714-5722,共9页Chinese Traditional and Herbal Drugs

基　　金：天津市科技计划项目“生态材料与低产土壤高价值利用技术研究”(23ZGCXQY00060)。

摘　　要：亚精胺是一类天然的多胺,普遍存在于鱼类、家禽等动物,谷物、蔬菜、中草药等植物以及乳酸菌、双歧杆菌等微生物细胞中,具有抗衰老、抗氧化、抗炎、心血管保护等多种药理作用。目前亚精胺在保健品、医药、植物生理等领域得到国内外的广泛研究。通过查阅亚精胺国内外相关文献资料并结合文献计量学,对亚精胺的植物源、动物源性食品、体内合成等多种来源,体内吸收、代谢、分布,药理作用及开发应用进行系统综述,以期为亚精胺在药品、保健品、化妆品等方面的开发应用提供参考。Spermidine is a kind of natural polyamine,widely existing in fish,poultry and other animals,grains,vegetables,Chinese herbs and other plants,as well as lactic acid bacteria,bifidobacteria and other microbial cells,and has anti-aging,anti-oxidation,anti-inflammatory,cardiovascular protection and other pharmacological effects.Spermidine has been widely studied in the fields of health care products,medicine and plant physiology at home and abroad.By referring to the relevant literature at home and abroad and combining with bibliometrics,this paper systematically reviews the plant source,animal source food,in vivo synthesis and other sources,in vivo absorption,metabolism,distribution,pharmacological action and development and application of spermidine,in order to provide reference for the development and application of spermidine in drugs,health products,cosmetics and other aspects.

关 键 词：亚精胺 多胺 代谢 文献计量学 开发应用 

分 类 号：R284.1[医药卫生—中药学]