探讨慢性萎缩性胃炎伴肠上皮化生的用药规律信息学研究  

Medication Rules for Chronic Atrophic Gastritis with Intestinal Metaplasia Based on Data Mining

作　　者：纪天舒 袁泉 王苏童 薛晔 王永森[3] JI Tianshu;YUAN Quan;WANG Sutong;XUE Ye;WANG Yongsen(Shandong University of Traditional Chinese Medicine,Jinan 250014;Qingdao Traditional Chinese Medicine Hospital(Qingdao Hiser Hospital),Qingdao Hiser Hospital Affiliated of Qingdao University,Qingdao266000;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014)

机构地区：[1]山东中医药大学,济南250014 [2]青岛市中医医院(市海慈医院)青岛大学附属青岛市海慈医院,青岛266000 [3]山东中医药大学附属医院,济南250014

出　　处：《中药药理与临床》2024年第7期86-93,共8页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家重点实验室开放课题(编号:SKL-BMSG2022-02);国家自然青年科学基金项目(编号:81904128)。

摘　　要：目的:分析中医药治疗慢性萎缩性胃炎(Chronic atrophic gastritis)伴肠上皮化生(Intestinal epithelial metaplasia)的用药规律,为临床治疗提供理论参考。方法:借助中国知网、万方数据、维普中文期刊数据库,检索慢性萎缩性胃炎伴肠上皮化生治疗的相关文献,建立Excel数据库进行高频药物、性味归经及其证候要素的描述性统计,借助SPSS Statistics 23.0进行聚类分析、SPSS Modeler 18.0进行关联规则分析、Lantern 5.0软件进行隐结构分析。结果:研究录入相关文献165篇,处方214首,药物229味,用药总频次2642次,核心中药47味(使用频次>15),以甘草、白术、白芍、半夏、茯苓等应用较广。并根据最大剂量、常用剂量和最小剂量,对47味高频中药进行药物剂量统计。性味以甘温为最,归经以肝经为首。提取出病位证素6个,脾、胃、肝位居前列;病性证素12个,气虚、血瘀、气滞频次较高。以置信度>85%,支持度>10%,提升度>1进行关联规则分析得到常用三联药对组合11对;并对高频药物、高频证型汇总进行关联分析,按照置信度>90%,支持度>2%,提升度>1,按证型分类,自高至低筛选前5位关联组合,共得到关联组合40对。隐结构分析得出47个隐变量、7个隐类,总结得出5个综合聚类模型。结论:CAG伴IM多见虚实夹杂证,脾胃亏虚、本虚标实是本病的关键所在。临床治疗以“健脾益胃、扶正祛邪”为基础。虚则补益,健脾、益胃、补肾、滋肺以扶正;实则泻之,利湿、清热、散寒、化瘀、解毒以祛邪。Objective:To analyze the medication rules of traditional Chinese medicine(TCM) in the treatment of chronic atrophic gastritis(CAG) with intestinal metaplasia(IM) to provide theoretical references for clinical treatment. Methods:CNKI,Wanfang Data, and VIP were searched for relevant literature on the treatment of CAG with IM. Excel database was established for descriptive statistics of high-frequency drugs, Xing(性),Wei(味),Guijing(归经),and syndrome elements. SPSS Statistics 23.0 was used for cluster analysis, SPSS Modeler 18.0 for association rule analysis, and Lantern 5.0 for hidden structure analysis. Results:A total of 165 research articles were included, involving 214 prescriptions, 229 drugs with a total frequency of 2 642 times, and 47 core drugs with a frequency>15,and Gancao(甘草),Baizhu(白术),Baishao(白芍),Banxia(半夏),and Fuling(茯苓) were widely used. According to the maximum dosage, common dosage, and minimum dosage, 47 high-frequency drugs were analyzed. In terms of Xing and Wei, drugs were mainly Gan(甘) and Wen(温),and in terms of Guijing, drugs mainly acted on the Ganjing(肝经). Six syndrome elements on disease location were extracted, which were represented by Pi(脾),Wei(胃),and Gan(肝),and 12 syndrome elements on disease property were extracted, which were represented by Qixu(气虚),Xueyu(血瘀),and Qizhi(气滞). Association rule analysis was conducted with confidence>85%,support >10%,and lift >1,and 11 triplet combinations of drugs were obtained. Association rule analysis was carried out on high-frequency drugs and high-frequency syndrome. The top 5 association combinations were screened from high to low according to the classification of syndrome with confidence > 90%,support >2%,and lift >1,and 40 association combinations were obtained. Forty-seven hidden variables and seven hidden classes were obtained from the analysis of hidden structure, and five comprehensive clustering models were summarized. Conclusion:CAG with IM is common in Xushijiaza(虚实夹杂) syndrome,

关 键 词：慢性萎缩性胃炎 数据挖掘 肠上皮化生 证素 关联规则 隐结构 

分 类 号：R259[医药卫生—中西医结合]