基于肠道微生态调控研究中医药防治艾滋病的作用探讨  

Mechanisms of TCM in Preventing and Treating AIDS Based on Intestinal Microecology Regulation

作　　者：许前磊[1,2,3] 胡新宁 张欣欣 许向前[4] 李青雅[1,3] 李强[2,3] 张淼 桑锋[2,3] XU Qianlei;HU Xinning;ZHANG Xinxin;XU Xiangqian;LI Qingy;LI Qiang;ZHANG Miao;ANG Feng(Henan University of Chinese Medicine,Zhengzhou 450046;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000;Henan Key Laboratory of Viral Diseases Control with Traditional Chinese Medicine,Zhengzhou 450008;The Second Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450002)

机构地区：[1]河南中医药大学,郑州450046 [2]河南中医药大学第一附属医院,郑州450000 [3]河南省病毒性疾病中医药防治重点实验室,郑州450008 [4]河南中医药大学第二附属医院,郑州450002

出　　处：《中药药理与临床》2024年第7期102-106,共5页Pharmacology and Clinics of Chinese Materia Medica

基　　金：“中原英才计划(育才系列)”中原青年拔尖人才(编号:ZYYCYU202012153);河南省自然科学基金项目(编号:222300420059);河南省科技攻关项目(编号:212102311126);河南省中医药科学研究专项课题(编号:20-21ZY1047、2022ZY1032);河南省特色骨干学科中医学学科建设项目(编号:STG-ZYXKY-2020026、STG-ZYX06-202147)。

摘　　要：中医药在延缓艾滋病感染者发病、调节免疫功能、改善临床症状、提高生存质量等方面具有优势,但由于艾滋病临床症状复杂多样,中医证候多虚实夹杂,临床辨治组方配伍药味较多,造成单一靶点和途径难以阐明中医药治疗HIV/AIDS的作用机制。本文通过查阅国内外文献,对HIV/AIDS肠道微生态研究现状及肠道微生态在中医药防治艾滋病临床实践进行综述,提出应用16s rDNA、宏基因组、流式细胞术、ELISA等技术,对艾滋病患者的肠道菌群多样性、肠黏膜屏障通透性和完整性改变、肠道免疫进行研究,进一步研究中医药通过调控肠道菌群对肠道粘膜屏障及肠道免疫的保护作用,明确中医药对肠道微生态调控发挥的多靶点、多环节作用的内在机制。Traditional Chinese medicine(TCM) has advantages in delaying the onset of disease in HIV-infected individuals, regulating immune function, improving clinical symptoms, and enhancing the quality of life. However, due to the complex and diverse clinical symptoms of HIV/AIDS,TCM syndrome is characterized by Xushijiaza(虚实夹杂),leading to the use of multiple Chinese herbal drugs in clinical treatment. This complexity makes it challenging to elucidate the mechanisms of action of TCM in the treatment of HIV/AIDS,as it does not act on a single target or pathway. This study reviewed the current status of research on the intestinal microecology in HIV/AIDS and its clinical application in TCM practice, proposed the use of techniques such as 16s rDNA sequencing, metagenomics, flow cytometry, and ELISA to study the diversity of gut microbiota in HIV/AIDS patients, changes in intestinal mucosal barrier permeability and integrity, and intestinal immune responses, and further investigated how TCM regulated the gut microbiota to protect the intestinal mucosal barrier and enhance intestinal immunity. This study is expected to clarify the underlying mechanisms by which TCM exerts its multi-target and multi-stage effects on the regulation of intestinal microecology.

关 键 词：艾滋病 肠道微生态 调控 中医药 机制 

分 类 号：R285[医药卫生—中药学]