基于真实世界的痰热清注射液临床用药特征研究  

A study on clinical medication characteristics of Tanreqing injection based on real-world

作　　者：孙晨曦 张凤 姚亚敏 徐峰 宋钟娟 李国文[5] 黄瑾 陈敏 任炳楠[8] 高飞 刘力[2] 陈万生 SUN Chenxi;ZHANG Feng;YAO Yamin;XU Feng;SONG Zhongjuan;LI Guowen;HUANG Jin;CHEN Min;REN Bingnan;GAO Fei;LIU Li;CHEN Wansheng(Department of Pharmacy,Second Affiliated Hospital of Naval Medical University,Shanghai 200003,China;Department of Pharmacy,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China;Department of Pharmacy,Fengxian District Central Hospital,Shanghai 201499,China;Department of Pharmacy,Huadong Hospital,Fudan University,Shanghai 200040,China;Department of Pharmacy,Shanghai TCM-Integrated Hospital,Shanghai 200082,China;Department of Pharmacy,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;Department of Pharmacy,Shanghai Pudong District Zhoupu Hospital,Shanghai 201318,China;Department of Pharmacy,Hebei general Hospital,Shijiazhuang,050051;Beijing Nordo Cognitive Medical Technology Co.,Ltd.,Beijing 102600,China)

机构地区：[1]海军军医大学第二附属医院药剂科,上海200003 [2]上海中医药大学附属曙光医院药学部,上海200021 [3]上海市奉贤区中心医院药学部,上海201499 [4]复旦大学附属华东医院药剂科,上海200040 [5]上海市中西医结合医院药剂科,上海200082 [6]上海中医药大学附属岳阳中西医结合医院药学部,上海200437 [7]上海市浦东新区周浦医院药剂科,上海201318 [8]河北省人民医院药学部,石家庄050051 [9]北京诺道认知医学科技公司,北京102600

出　　处：《中国临床药学杂志》2024年第7期481-487,共7页Chinese Journal of Clinical Pharmacy

基　　金：国家自然科学基金(编号81830109);国家自然科学基金联合重点项目(编号U23A20512);海军军医大学“深蓝工程”远航人才计划(编号SL33);上海市药学会药品综合评价科研项目(编号SHYXH-ZP-2021-009)。

摘　　要：目的通过分析真实世界中痰热清注射液的临床用药特征,为痰热清注射液的临床合理应用提供参考。方法收集2015年1月至2023年12月10家三级甲等医疗机构中使用痰热清注射液治疗的住院病例,提取病例的年龄、性别、住院科室、住院时间、疾病诊断、实验室检查和用药情况等信息,分析痰热清注射液的临床用药特征。结果纳入使用痰热清注射液的病例共18854例,男女比例1.12∶1,年龄[62(49,72)]岁,住院时间[9(6,13)]d。诊断方面,呼吸系统疾病占比最高(占59.02%);实验室检查方面,C反应蛋白和中性粒细胞百分比高于正常参考值的病例占比较高。18854例病例单次用药剂量为(27.69±7.11)mL,99.75%的医嘱中给药频次为qd,用药天数[5(2,9)]d,累积用药剂量[120(60,240)]mL,给药方式均为静脉滴注,以0.9%氯化钠注射液作为溶媒的占60.3%;联用药物中,联用抗菌药物占比最高(占53.55%),联用1种抗菌药物中联用β-内酰胺类药物占比最高(占42.5%),联用2种抗菌药物中联用β-内酰胺类药物+喹诺酮类药物最为多见(置信度63.27%)。用药14 d内,疾病缓解率呈上升趋势。结论痰热清注射液主要用于呼吸系统疾病合并感染的治疗,真实世界中用法用量与药品说明书相符,临床常与抗菌药物联用,大部分患者在用药14 d内获益明显。AIM To analyze potential issues in the clinical application of Tanreqing injection and propose corresponding solutions,by analyzing the characteristics of Tanreqing injection in the real world.METHODS Hospitalized patients treated with Tanreqing injection in 10 tertiary medical institutions from January 2015 to December 2023 were collected.The information of age,gender,hospitalization department,hospitalization time,disease diagnosis,laboratory examination,medication status and other information were extracted,and clinical medication characteristics of Tanreqing injection were analyzed.RESULTS A total of 18854 patients were included,with a male-to-female ratio of 1.12∶1.The average age was 62(49,72)years,and the length of hospital stay was 9(6,13)days.In diagnostic information,lung-related diseases accounted for the highest proportion(59.02%).Regarding laboratory tests,levels of C-reactive protein and the percentage of neutrophils were above normal reference ranges.The single dose of the medication was(27.69±7.11)mL,and 99.75%of the medical instructions prescribed a frequency of once daily(qd).The duration of medication use was 5(2,9)days,with the cumulative dose amounting to 120(60,240)mL.Administration was exclusively by intravenous drip,and 0.9%sodium chloride injection solution served as the solvent in 60.3%of the cases.Among the combined medications,antibacterial drugs accounted for the highest proportion(53.55%).Within the single antibacterial drug combinations,β-lactam drugs made up the highest proportion at 42.5%.The combination ofβ-lactam drugs and quinolones was the most common among the combinations of 2 antibacterial drugs,with a confidence level of 63.27%.Within 14 days of medication,the disease remission rate showed an upward trend.CONCLUSION Tanreqing injection is mainly used for the treatment of respiratory diseases complicated with infection.The usage and dosage are consistent with the instructions.It is frequently combined with antibacterial drugs in clinical practice.Most patients benefit

关 键 词：痰热清注射液 真实世界研究 临床用药特征 关联规则分析 

分 类 号：R286[医药卫生—中药学]