基于PCNE分类系统的肿瘤化学治疗患者药物相关问题分析  

Study on drug-related problems in patients with cancer chemotherapy based on PCNE classification system

作　　者：吴凡 封甦婷 朱斌 陈玲[1,2] WU Fan;FENG Suting;ZHU Bin;CHEN Ling(Department of Pharmacy,Fudan University Shanghai Cancer Center,Shanghai 200032,China;Department of Clinical Oncology,Shanghai Medical College of Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属肿瘤医院药剂科,上海200032 [2]复旦大学上海医学院肿瘤学系,上海200032

出　　处：《中国临床药学杂志》2024年第7期502-508,共7页Chinese Journal of Clinical Pharmacy

摘　　要：目的运用欧洲医药保健网(PCNE)分类系统对肿瘤化学治疗(简称“化疗”)患者用药期间所产生的药物相关问题(DRPs)进行分析,为肿瘤化疗患者的药学监护提供参考。方法在药学化疗门诊宣教小程序和医院管理信息系统(HIS)中收集2020年5月至2023年5月肿瘤化疗患者的用药咨询记录,采用PCNE(9.1版)分类系统评估DRPs,对DRPs的类型、原因和干预措施等因素进行分析。结果共收集到943份用药咨询记录,临床药师共确定674个DRPs,最常见DRPs的类型为“治疗安全性和有效性”(占97.48%)。在原因类型中,“可能发生的不良事件”占比最高(占78.2%),其次是“患者摄取与使用的药物有相互作用的食物”(占6.8%)和“患者用药时间或用药间隔不适当”(占5.0%)。针对674个的DRPs,临床药师提出846项干预措施,其中针对药物的干预措施有601项(占71.0%),针对患者的干预措施有165项(占19.5%)。共有725项(占85.7%)干预措施被接受,523个(占77.6%)DRPs被解决。结论利用PCNE分类系统有助于精准分析DRPs,为肿瘤化疗患者提供个体化的药学监护,促进临床合理用药,同时提高临床药师的工作效率和工作积极性。AIM To analyze the drug-related problems(DRPs)by using the Pharmaceutical Care Network Europe(PCNE)classification system to provide reference for pharmaceutical monitoring of patients undergoing cancer chemotherapy.METHODS The medication consultation records of tumor chemotherapy patients from May 2020 to May 2023 were collected in the pharmacy chemotherapy outpatient mission program and hospital management information system(HIS).DRPs were evaluated by PCNE 9.1 classification system,and the type,cause and intervention of DRPs were analyzed.RESULTS A total of 943 pharmacy consultation records were collected,and 674 DRPs were identified by clinical pharmacists,and the most common DRPs were"treatment safety and efficacy"(97.48%).Among the cause types,"possible adverse events"accounted for the highest proportion(78.2%),followed by"food interacting with the drug used"(6.8%)and"inappropriate medication time or interval between patients"(5.0%).For 674 DRPs,clinical pharmacists proposed 846 interventions,including 601 interventions at the drug level(71.0%)and 165 interventions at the patient level(19.5%).A total of 725 interventions were accepted(85.7%),and 523 DRPs were resolved(77.6%).CONCLUSION PCNE classification system is helpful for accurate analysis of DRPs,providing personalized pharmaceutical monitoring for patients with tumor chemotherapy,promoting rational clinical drug use,and improving the work efficiency and enthusiasm of clinical pharmacists.

关 键 词：欧洲医药保健网分类系统 药物相关问题 肿瘤化疗患者 药学监护 

分 类 号：R969.3[医药卫生—药理学]