抗寄生虫微管蛋白抑制剂的研究进展  

Research progress on microtubule protein inhibitors with antiparasitic effect

作　　者：达哇卓玛 刘川川 樊海宁[4] DAWA Zhuoma;LIU Chuanchuan;FAN Haining(Translational Center for High Altitude Clinical Medicine,Qinghai Provincial People’s Hospital,Xining 810007,China;Research Center for High Altitude Medicine,Medical College of Qinghai University,Xining 810001,China;Qinghai Province Key Laboratory of Hydatid Disease Research,Qinghai University Affiliated Hospital,Xining 810000,China;Department of Hepatobiliary Surgery,Qinghai University Affiliated Hospital,Xining 810000,China)

机构地区：[1]青海省人民医院高原临床医学转化中心,青海西宁810007 [2]青海大学医学院高原医学研究中心,青海西宁810001 [3]青海大学附属医院青海省包虫病研究重点实验室,青海西宁810000 [4]青海大学附属医院肝胆胰外科,青海西宁810000

出　　处：《现代药物与临床》2024年第8期2182-2186,共5页Drugs & Clinic

基　　金：青海省基础研究计划项目(2023-0302-ZJC-0125);青海省“昆仑英才·高端创新创业人才”项目。

摘　　要：微管蛋白抑制剂特异性作用于微管蛋白、干扰细胞有丝分裂、造成细胞周期停滞,从而诱导细胞凋亡。微管蛋白抑制剂按其结合部位可分为作用于秋水仙碱位点、长春花碱位点和紫杉醇位点的抗寄生虫微管蛋白抑制剂。综述了微管蛋白抑制剂抗寄生虫病的研究进展及其作用机制,旨在对抗寄生虫药物的研究提供参考。Microtubule protein inhibitors specifically act on microtubules,interfere with cell mitosis,cause cell cycle arrest,and induce cell apoptosis.Microtubule protein inhibitors can be classified as antiparasitic microtubule protein inhibitors that act on colchicine sites,vinblastine sites,and paclitaxel sites according to their binding sites.This article reviews the research progress and its mechanism of microtubule protein inhibitors against parasitic diseases,aiming to provide reference for the study of antiparasitic drugs.

关 键 词：微管蛋白抑制剂 抗寄生虫 秋水仙碱位点 长春花碱位点 紫杉醇位点 

分 类 号：R962[医药卫生—药理学]