Anti-skin aging effects and bioavailability of collagen tripeptide and elastin peptide formulations in young and middle-aged women  

作　　者：Shan Lu Silu Zhang Yun Wang Jiayi Ni Tiantian Zhao Guoxun Xiao 

机构地区：[1]Wonderlab Innovation Centre for Healthcare,Shenzhen Porshealth Bioengineering Co,Ltd.,Shenzhen 518116,China [2]Sericulture&Agri-food Research Institute Guangdong Academy of Agricultural Sciences,Key Laboratory of Functional Foods,Ministry of Agriculture and Rural affairs,Guangdong Key Laboratory of Agricultural Products Processing,Guangzhou,Guangdong 510610,China [3]Department of Dermatology,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200125,China [4]Sprim(China)Consulting Co.Ltd.,Shanghai 201201,China [5]Department of Food Science,Rutgers University,New Brunswick,NJ 08901,United States

出　　处：《Journal of Dermatologic Science and Cosmetic Technology》2024年第2期26-37,共12页皮肤科学与化妆品技术期刊（英文）

摘　　要：Background:Collagen peptides(CP),including tripeptides and elastin peptides(EP),are known for their in vitro and in vivo anti-skin aging effects.Despite positive results in animal models,the combination effects of CP and EP and the bioavailability of CP in human studies,particularly in young and middle-aged women,remain underexplored.Objective:To evaluate the effects of an orally administered collagen drink combining CP and EP on the skin health of young and middle-aged women.Materials and Methods:A single-center,randomized,double-blind,parallel-controlled trial was conducted,utilizing the WONDERLABR fish collagen tripeptide beverage.Participants consumed the drink over an 8-week period.Results:Compared to the placebo group,the collagen drink group showed significant improvements in skin hydration(39.19%increase),transepidermal water loss(33.45%decrease),skin elasticity(25.37%increase),dermal collagen content(21.64%increase),pore size(7.94%decrease),wrinkle length(18.09%decrease),skin smoothness(2.85%improvement),and skin roughness(15.32%decrease).Overall pore volume decreased by 60%,and visual assessments indicated a decrease in skin luminosity by 15.20%and smoothness index by 22.55%.Mass spectrometry demonstrated a significant increase in collagen efficacy components,including blood pH and GPH levels(P<0.05).Conclusion:The study confirmed the combination nourishing and anti-skin aging effects of EP and CP on the skin of young and middle-aged women,demonstrating significant improvements in various skin parameters and good bioavailability of collagen peptides.

关 键 词：Collagen tripeptides Elastin peptides ANTI-AGING Skin protection Peptide absorption 

分 类 号：R751[医药卫生—皮肤病学与性病学]