药学类专业多维实践能力培养模式探索——以“基于响应面法对婴幼儿读物中荧光增白剂检测方法的优化”为例  

Exploration of Multi-dimensional Practical Ability Training Model for Pharmaceutical Majors:Taking“Optimization of Fluorescent Brightener Detection Method in Infant Reading Materials Based on Response Surface Methodology”as An Example

作　　者：徐菲[1,2] 冯睿思 肖婷芬 何方惠 王志琪[1,2] 陈畅 Xu Fei;Feng Ruisi;Xiao Tingfen;He Fanghui;Wang Zhiqi;Chen Chang(Hunan University of Traditional Chinese Medicine,College of pharmacy,Changsha 410208,China;Hunan University of Traditional Chinese Medicine,Hunan Province Sino-US International Joint Research Center for Therapeutic Drugs of Senile Degenerative,Changsha 410208,China)

机构地区：[1]湖南中医药大学,药学院,湖南长沙410208 [2]湖南中医药大学,湖南省中美老年性退行性疾病治疗药物国际联合研究中心,湖南长沙410208

出　　处：《广东化工》2024年第17期224-228,共5页Guangdong Chemical Industry

基　　金：湖南省普通高等学校教学改革研究项目(HNJG-2021-0590);湖南中医药大学“实验室管理研究”专项课题(Sysgl202206)。

摘　　要：以仪器分析实验中荧光分光光度法的定量分析应用为基础,设计以“兴趣牵引”为导向的综合性探索实验:荧光增白剂定量分析,荧光分光光度法和响应曲面设计统计方法的综合应用。学生充分参与完整仪器分析实验流程,有效提高了学生的综合思维能力和解决实际问题的能力。“婴幼儿读物中荧光增白剂检测方法的优化”是仪器分析实验课程中以“兴趣为导向”的探索研究型实验,它涵盖了荧光分光光度法原理探究、实验条件设置等科研基本能力的训练。该实验采用响应面法对萃取时间、温度和试剂用量等考察,鼓励学生基于实际问题,尝试优化现行荧光增白剂检测方案。Based on the application of quantitative analysis of fluorescence spectrophotometry in instrumental analysis experiments,we design a comprehensive exploration experiment oriented by“interest pulling”,which includes the quantitative analysis of fluorescent whitening agents,the comprehensive application of fluorescence spectrophotometry and statistical methods of response surface design.During the experimental process,students fully participate in the complete instrumental analysis experimental process,which effectively improves students'comprehensive thinking ability and practical problem solving ability.“Optimisation of Fluorescent Brightener Detection Methods in Infant and Children's Books”is an“interest-oriented”exploratory experiment in the instrumental analysis experimental course,which covers the investigation of the principle of fluorescence spectrophotometry,experimental conditions,and other basic scientific research ability training.The experiment adopts response surface methodology to investigate the extraction time,temperature and reagent dosage,encouraging students to try to optimise the current fluorescent whitening agent detection scheme based on practical problems.

关 键 词：荧光增白剂 荧光分光光度法 响应面分析法 

分 类 号：TQ410[化学工程]