G protein-mediated signal transduction: a molecular choreography of G protein activation after GTP binding  

作　　者：Evi Kostenis Lars Jurgenliemke Judith Alenfelder 

机构地区：[1]Department of Molecular-,Cellular-,and Pharmacobiology,Institute of Pharmaceutical Biology,University of Bonn,Bonn,Germany [2]Graduate Training Group RTG2873,University of Bonn,Bonn,Germany

出　　处：《Signal Transduction and Targeted Therapy》2024年第8期3155-3157,共3页信号转导与靶向治疗（英文）

基　　金：The authors'research is supported by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)with FOR2372/project number 290847012 to E.K.;RTG2873/projectnumber 494832089 to E.K.and LJ.

摘　　要：A recent report from the Skiniotis group,'published in Nature,provides fascinating insight into the molecular choreography underlying a quintessential cellular signaling mechanism:G protein-mediated signal transduction.Using time-resolved cryo-EM,the authors pieced together many sequential structural snapshots to visualize how a trimeric aβy G protein-after being convinced by its activated G protein-coupled receptor(GPCR)to release GDP-picks up GTP,to set in motion finely tuned conformational transitions that lead to the conversion into the active state and,finally,subunit dissociation as well as disengagement from the receptor.

关 键 词：SKIN ACTIVATION finally 

分 类 号：Q51[生物学—生物化学]