定量MRI分析2型糖尿病患者肝胰脂肪含量与胰岛β细胞功能、骨密度的关系  

Quantitative MRI analysis of hepatic and pancreatic fat content in patients with type 2 diabetes mellitus and the relationship with pancreaticβ-cell function and bone mineral density

作　　者：郑晓宾[1] 邓捷 朱亦堃[3] ZHENG Xiaobin;DENG Jie;ZHU Yikun(Department of Radiology,Heji Hospital Affiliated to Changzhi Medical College,Changzhi,Shanxi Province 046011,China;Department of Endocrinology,the Second Hospital of Luzhou District,Changzhi City,Changzhi,Shanxi Province 046000,China;Department of Endocrinology,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]长治医学院附属和济医院影像科,山西长治046011 [2]长治市潞州区第二医院内分泌科,山西长治046000 [3]山西医科大学第二医院内分泌科,山西太原030001

出　　处：《实用放射学杂志》2024年第8期1304-1307,1353,共5页Journal of Practical Radiology

摘　　要：目的探讨定量MRI分析2型糖尿病(T2DM)患者肝胰脂肪含量变化及其与胰岛β细胞功能、骨密度(BMD)的关系。方法选取118例T2DM患者(T2DM组)为研究对象,并选取同期进行体检的100例健康对照(HC)(HC组),所有患者均进行MRI检查,采用多回波水脂分离(IDEAL-IQ)技术检测肝脏脂肪分数(HFF)和胰腺脂肪分数(PFF),应用稳态模型评估胰岛β细胞功能指数(HOMA-β)、稳态模型评估胰岛素抵抗指数(HOMA-IR),应用双能X线吸收仪检测L2~L4、股骨颈和全髋BMD,采用Pearson分析HFF、PFF与HOMA-β、HOMA-IR和L2~L4、股骨颈和全髋BMD的相关性。结果T2DM组HFF、PFF为(14.12±2.19)%、(8.23±1.60)%,高于HC组的(5.30±0.83)%、(4.36±0.85)%,比较差异有显著性意义(P<0.05)。T2DM组HOMA-β为14.50±3.63,L2~L4、股骨颈和全髋BMD为(0.92±0.13)mg/cm^(3)、(0.77±0.10)mg/cm^(3)、(0.83±0.12)mg/cm^(3),低于HC组的25.22±5.43、(1.05±0.23)mg/cm^(3)、(0.85±0.18)mg/cm^(3)、(0.91±0.20)mg/cm^(3);T2DM组HOMA-IR为3.56±1.22,高于HC组的1.90±0.45,比较差异有显著性意义(P<0.05)。Pearson相关分析显示,HFF、PFF与HOMA-β及L2~L4、股骨颈和全髋BMD呈负相关,与HOMA-IR呈正相关(P<0.05)。结论MRI可定量评估T2DM患者肝胰脂肪含量,且肝胰脂肪含量与胰岛HOMA-β、HOMA-IR、BMD密切相关。Objective To explore the changes of hepatic and pancreatic fat content in patients with type 2 diabetes mellitus(T2DM)using quantitative MRI,and to discuss the relationship with pancreaticβ-cell function and bone mineral density(BMD).Methods A total of 118 patients with T2DM(T2DM group)were selected as the research subjects.At the same time,100 healthy control(HC)(HC group)who received physical examination were selected.All patients were examined with MRI.Hepatic fat fraction(HFF)and pancreatic fat fraction(PFF)were detected using the iterative decomposition of water and fat with echo asymmetry and least square estimation quantitation(IDEAL-IQ)technology.The homeostasis model assessment ofβ-cell function(HOMA-β)and homeostasis model assessment of insulin resistance(HOMA-IR)were performed.BMD of L2-L4,femoral neck and total hip were measured by dual-energy X-ray absorptiometry.The correlations among HFF,PFF and HOMA-β,HOMA-IR and BMD of L2-L4,femoral neck and total hip were analyzed by Pearson method.Results HFF and PFF in the T2DM group[(14.12±2.19)%and(8.23±1.60)%]were higher than those in the HC group[(5.30±0.83)%and(4.36±0.85)%],with statistically significant differences(P<0.05).HOMA-βand BMD of L2-L4,femoral neck and total hip in the T2DM group[14.50±3.63,(0.92±0.13)mg/cm^(3),(0.77±0.10)mg/cm^(3)and(0.83±0.12)mg/cm^(3)]were lower than those in the HC group[25.22±5.43,(1.05±0.23)mg/cm^(3),(0.85±0.18)mg/cm^(3)and(0.91±0.20)mg/cm^(3)].HOMA-IR in the T2DM group(3.56±1.22)was higher than that in the HC group(1.90±0.45).The differences were statistically significant(P<0.05).Pearson correlation analysis found that HFF and PFF were negatively correlated with HOMA-βand BMD of L2-L4,femoral neck and total hip,and were positively correlated with HOMA-IR(P<0.05).Conclusion MRI can be used to quantitatively evaluate hepatic and pancreatic fat content in patients with T2DM.In addition,hepatic and pancreatic fat content are closely related to pancreatic HOMA-β,HOMA-IR and BMD.

关 键 词：2型糖尿病 肝胰脂肪含量 定量MRI分析 胰岛Β细胞功能 骨密度 

分 类 号：R587.1[医药卫生—内分泌] R445.2[医药卫生—内科学]