不同Braunwald分级的不稳定型心绞痛患者血清ESM-1、MMP-9、GMP140水平变化及与其疾病转归的相关性  

Changes in serum ESM-1,MMP-9 and GMP140 levels in patients with unstable angina with different Braunwald classifications and their correlation with disease regression

作　　者：郭亚蕾 Guo Yalei(The Second People's Hospital of Pingdingshan Henan,Pingdingshan 467000)

机构地区：[1]平顶山市第二人民医院,河南平顶山467000

出　　处：《辽宁医学杂志》2024年第4期22-25,共4页Medical Journal of Liaoning

摘　　要：目的探讨不同Braunwald分级的不稳定型心绞痛(UA)患者血清内皮细胞特异分子-1(ESM-1)、基质金属蛋白酶-9(MMP-9)、血小板颗粒膜蛋白140(GMP140)水平变化及与其疾病转归的相关性。方法选取我院2020年7月至2021年9月收治的116例UA患者为研究对象,对比不同Braunwald分级、是否发生主要心血管事件(MACE)患者的血清ESM-1、MMP-9、GMP140水平,分析血清ESM-1、MMP-9、GMP140水平与疾病转归的相关性以及对于MACE的预测价值。结果三组入院时血清ESM-1、MMP-9、GMP140水平比较:Ⅰ级患者<Ⅱ级患者<Ⅲ级患者(P<0.05);与非MACE患者相比,治疗4、8周后MACE患者血清ESM-1、MMP-9、GMP140水平较高(P<0.05);治疗4、8周后血清ESM-1、MMP-9、GMP140水平与疾病转归呈正相关(P<0.05);ROC曲线结果显示,治疗4、8周后血清ESM-1、MMP-9、GMP140水平联合检测发生MACE的AUC分别为0.806、0.890,优于各指标单一指标(P<0.05)。结论血清ESM-1、MMP-9、GMP140水平随UA患者Braunwald分级的升高而上升,且联合应用时可有效预测MACE发生风险。Objective To investigate the changes in serum endothelial-specific molecule-1(ESM-1),matrix metalloproteinase-9(MMP-9),and platelet granule membrane protein 140(GMP140)levels in patients with unstable angina(UA)of different Braunwald classifications and the correlation with their disease regression.Methods One hundred and sixteen UA patients admitted to our hospital from July 2020 to September 2021 were selected for the study,and the serum ESM-1,MMP-9,and GMP140 levels of patients with different Braunwald classifications and whether they had major cardiovascular events(MACE)were compared to analyze the correlation between serum ESM-1,MMP-9,and GMP140 levels and disease regression and the predictive value for MACE.Results Comparison of serum ESM-1,MMP-9,and GMP140 levels at admission in the three groups:Class I patients<Class II patients<Class III patients(P<0.05);serum ESM-1,MMP-9,and GMP140 levels were higher in MACE patients after 4 and 8 weeks of treatment compared with non-MACE patients(P<0.05);serum ESM-1,MMP-9,and GMP140 levels after 4 and 8 weeks of treatment-9 and GMP140 levels were positively correlated with disease regression after 4 and 8 weeks of treatment(P<0.05);the ROC curve results showed that the AUC of serum ESM-1,MMP-9 and GMP140 levels combined to detect the occurrence of MACE after 4 and 8 weeks of treatment was 0.806 and 0.890,respectively,which was better than each index alone(P<0.05).Conclusion Serum ESM-1,MMP-9,and GMP140 levels increased with Braunwald classification in UA patients and were effective in predicting the risk of MACE when combined.

关 键 词：不稳定型心绞痛 Braunwald分级 疾病转归 ESM-1 MMP-9 GMP140 

分 类 号：R541.4[医药卫生—心血管疾病]