肾窦异位脂肪沉积对肾损伤影响的研究进展  

Research progress of ectopic fat deposition in renal sinus affecting renal injury

作　　者：王莎莎 韩甲 刘向云 Wang Shasha;Han Jia;Liu Xiangyun(College of Rehabilitation Sciences,Shanghai University of Medicine and Health Sciences,Shanghai 201318,China;School of Exercise and Health,Shanghai University of Sport,Shanghai 200438,China)

机构地区：[1]上海健康医学院康复学院,上海201318 [2]上海体育大学运动健康学院,上海200438

出　　处：《中华肾脏病杂志》2024年第8期685-690,共6页Chinese Journal of Nephrology

基　　金：上海健康医学院校级科研基金(SSF-24-03-01)。

摘　　要：异位脂肪沉积越来越被重视,尤其是具有局部效应的肝脏、心脏脂肪被研究较多,但是目前对肾窦异位脂肪沉积的研究较少。肾窦异位脂肪沉积增多对肾脏损害具有独立作用,但是其作用机制尚未清楚。本文将结合目前的研究从肾窦异位脂肪沉积相关影像学诊断、影响肾脏损伤的可能机制(肾窦异位脂肪沉积产生的机械性压力、脂毒性)以及目前对肾窦异位脂肪沉积的干预进行综述,以期研究者更多关注肾窦异位脂肪沉积在肾脏相关疾病发生、发展中的作用及其影响因素。The increasing focus and research on ectopic fat deposition,especially the locally impactful liver and cardiac fat,have been extensively studied.However,there has been relatively less research on renal sinus fat.The increased ectopic deposition of renal sinus fat has an independent effect on renal damage,but the underlying mechanism remains unclear.Therefore,this article will integrate current research to provide a comprehensive review of renal sinus ectopic fat deposition,covering its related imaging diagnosis,potential mechanisms influencing renal damage(mechanical pressure generated by renal sinus fat,lipotoxicity),and current interventions for renal sinus ectopic fat deposition.This is aimed at attracting more attention in clinical research to the role of renal sinus ectopic fat deposition in the occurrence and development of kidney-related diseases.

关 键 词：肥胖症 肾窦 异位脂肪沉积 机械压迫 脂毒性 

分 类 号：R692[医药卫生—泌尿科学]