Efficacy of nonsolvent flower pollen extracts in healthy women with urinary incontinence:A randomized,double-blind,placebo-controlled,parallel study  

作　　者：Marc Moulin Erin D.Lewis David C.Crowley Colleen E.May Malkanthi Evans 

机构地区：[1]KGK Science Inc.,London,Ontario,Canada [2]Graminex,L.L.C.,Saginaw,MI,USA

出　　处：《Current Urology》2024年第3期203-211,共9页当代泌尿学（英文）

基　　金：funded by Graminex L.L.C。

摘　　要：Background Urinary incontinence(UI)is a debilitating and common condition that adversely affects quality of life.Prescriptive and surgical approaches for managing UI symptoms may result in undesirable risks and complications.This randomized,double-blind,placebo-controlled,parallel study investigated the efficacy of 2 nonsolvent flower pollen extracts on UI in healthy women.Materials and methods One-hundred and fourteen women aged 40–75 years who scored≥5 on the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form(ICIQ-SF)were randomized to receive either Graminex®RCT Fem™UI,Graminex®PollenBerry®,or placebo for 24 weeks.The primary outcome was the change in the ICIQ-SF score between the trial and placebo groups after 24 weeks of supplementation.The secondary outcomes included changes in the frequency of nocturia(recorded in 3-day void diaries)and 24-hour leakage volume(assessed via pad weight)after 6,12,18,and 24 weeks of supplementation and changes in stress-induced urinary leakage volume(after completion of a provocative maneuver challenge)after 24 weeks of supplementation.Results All the groups demonstrated improvement in ICIQ-SF scores at week 24(p<0.001).The RCT Fem™UI group had the greatest improvement in ICIQ-SF scores(−4.07±3.4),followed by the PollenBerry®group(−3.34±2.87)and placebo group(−2.61±3.52).The RCT Fem™UI group had corresponding improvements in 24-hour leakage volume(−17.68±39.84 g)and frequency of nocturia(−0.52±1.26)(p≤0.05).PollenBerry®supplementation significantly improved stress-induced urinary leakage volume(−7.12±15.64 g)at week 24.The study products demonstrated safe hematological and chemical profiles.Conclusions RCT Fem™UI supplementation resulted in significant and clinically meaningful reductions in UI severity,with corresponding improvements in daily urinary leakage volume and frequency of nocturia.PollenBerry®significantly improved stress-induced urinary leakage volume,suggesting that it may be efficacious i

关 键 词：Urinary incontinence Pollen extract Healthy women Dietary supplement ICIQ-SF Urinary leakage 

分 类 号：R694.54[医药卫生—泌尿科学]