Relationship between serum vitamin D concentration and parameters of gonadal function in infertile male patients  

作　　者：Mariela Holzer Estefania Massa Sergio Ghersevich 

机构地区：[1]Laboratory of Biochemical Studies,Santa Fe,Argentina [2]Area of Clinical Biochemistry,Facultad de CienciasBioquimicas y Farmaceuticas,Universidad Nacional de Rosario,Rosario,Argentina

出　　处：《Current Urology》2024年第3期237-243,共7页当代泌尿学（英文）

摘　　要：Background Vitamin D(vitD)deficiency could affect male reproductive function.Our objective was to investigate the relationship between serum vitD concentrations and hormonal and seminal parameters in infertile patients and to compare the results with those in healthy controls.Materials and methods Infertile patients(n=29)and normozoospermic healthy donors(n=27)were recruited for the study.Serum concentrations of vitD,total testosterone,estradiol,and sex hormone-binding globulin were determined using chemiluminescence assays,and free testosterone concentration was determined by radioimmunoassay.Semen analysis was performed as suggested by the World Health Organization.Statistical analysis was conducted using Student’s t test,contingency tables,and linear regression studies.Results VitD concentrations were lower in patients than in controls(p<0.001).A significant association(p<0.001)was observed between vitD concentrations<20ng/mL and infertility.In the control group,significant correlations were reported between vitD concentrations>30 ng/mL and the concentrations of testosterone(p<0.05),free testosterone(p<0.01),and estradiol(p<0.05).A direct correlation was found between vitD concentration and percentage of sperm vitality(p=0.01).VitD also positively correlated with the percentage of progressive sperm motility(p<0.05)and sex hormone-binding globulin concentrations(p<0.01).Conclusions VitD may affect male reproductive parameters,and its deficiency could be associated with infertility.

关 键 词：INFERTILITY MALE SPERMATOZOA TESTOSTERONE Vitamin D 

分 类 号：R698.2[医药卫生—泌尿科学]