调胃承气汤治疗危重症脓毒症合并胃肠功能衰竭的临床研究  

A Clinical Study on the Treatment of Tiaowei Chengqi Decoction in Critically Ill Patients with Sepsis Complicated by Gastrointestinal Failure

作　　者：韩相如 赵雅丽 HAN Xiangru;ZHAO Yali(Henan Provincial Hospital of Traditional Chinese Medicine,The Second Affiliated Hospital of Henan University of Chinese Medicine,Henan Zhengzhou 450002)

机构地区：[1]河南省中医院河南中医药大学第二附属医院,河南郑州450002

出　　处：《深圳中西医结合杂志》2024年第13期16-19,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:分析研究危重症脓毒症合并胃肠功能衰竭患者使用调胃承气汤治疗的效果及对患者腹内压与炎症因子的影响。方法:选取32例在河南省中医院2018年2月至2022年12月确诊为危重症脓毒症合并胃肠功能衰竭患者作为回顾性研究对象。依据治疗方案不同分为对照组(17例)与观察组(15例)。对照组患者接受常规西医治疗,观察组患者接受常规西医+调胃承气汤治疗,比较不同方案的临床效果。结果:治疗后观察组患者急性生理与慢性健康状况Ⅱ(APACHEⅡ)、重症患者急性胃肠损伤(AGI)评分较对照组低,差异具有统计学意义(P<0.05);治疗后观察组患者腹内压较对照组低,肠鸣音次数较对照组多,差异具有统计学意义(P<0.05);治疗后观察组患者白细胞(WBC)计数、血清降钙素原(PCT)、血清C反应蛋白(CRP)水平较对照组低,差异具有统计学意义(P<0.05);观察组患者治疗总有效率为100.00%,较对照组的64.71%高,差异具有统计学意义(P<0.05)。结论:危重症脓毒症合并胃肠功能衰竭患者在常规西药治疗基础上增加使用调胃承气汤,可促进患者胃肠功能改善,有效降低腹内压及机体炎症因子水平,对疾病控制有利。Objective To study and analyze the effect of Tiaowei Chengqi Decoction on intra-abdominal pressure and inflammatory factors in critically ill patients with sepsis complicated by gastrointestinal failure.Methods A total of 32 patients diagnosed with critical sepsis complicated by gastrointestinal failure from February 2018 to December 2022 at Henan Provincial Hospital of Traditional Chinese Medicine were selected as the retrospective study subjects.They were divided into a control group(17 cases)and an observation group(15 cases)based on different treatment regimens.The control group received conventional Western medical treatment,while the observation group received conventional Western medicine plus Tiaowei Chengqi Decoction treatment.The clinical effects of different regimens were compared.Results After treatment,the acute physiology and chronic health evaluation II(APACHE II)and acute gastrointestinal injury(AGI)scores in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05);the intra-abdominal pressure in the observation group was lower than that in the control group,and the frequency of bowel sounds was higher than that in the control group,and the differences were statistically significant(P<0.05);the levels of white blood cell(WBC)count,serum procalcitonin(PCT),and serum C-reactive protein(CRP)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05);the total effective rate of treatment in the observation group was 100.00%,which was higher than 64.71%in the control group,and the difference was statistically significant(P<0.05).Conclusion Adding Tiaowei Chengqi Decoction to conventional Western medicine treatment for critically ill patients with sepsis complicated by gastrointestinal failure can promote the improvement of gastrointestinal function,effectively reduce intra-abdominal pressure and the level of inflammatory factors in the body,and is beneficial for disease

关 键 词：脓毒症 调胃承气汤 中西医结合疗法 

分 类 号：R631[医药卫生—外科学]