基于时间节律小柴胡汤加减治疗儿童变异性咳嗽对气道炎症水平的影响观察  

Influence of modified Xiaochaihu decoction based on time rhythm on airway inflammation level in children with cough variant asthma

作　　者：刘恒生 侯春光 金普放 LIU Hengsheng;HOU Chunguang;JIU Pufang(Department of TInternal Medicine of Chinese Medicine,Zhongzang Hospital,Jinchuan County,Jinchuan Sichuan 624100,China;Department of Traditional Chinese Medicine Pediatrics,Zhuji Traditional Chinese Medicine Hospital,Zhuji Zhejiang 311800,China)

机构地区：[1]金川县中藏医院中医内科,四川金川624100 [2]诸暨市中医院中医儿科,浙江诸暨311800

出　　处：《四川中医》2024年第9期116-119,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察基于时间节律小柴胡汤加减治疗儿童肺气亏虚证变异性咳嗽(CVA)对气道炎症水平的影响。方法:选择我院2021年5月~2023年5月收治的136例肺气亏虚证CVA患儿为研究对象,按随机数字法分为对照组(n=68)和中医组(n=68)。对照组使用小儿治哮灵片治疗,中医组使用小柴胡汤加减结合24节气治疗,比较治疗2周后两组临床疗效,对比治疗前、治疗2周后两组患儿中医症状积分和气道炎症水平变化情况,统计治疗过程中两组不良反应发生情况,观察用药结束后3个月内两组患儿咳嗽复发情况。结果:治疗2周后,中医组疗效明显高于对照组(P<0.05);两组患儿中医症状积分、IL-5、IL-8、IL-10、TNF-α水平较治疗前均有降低,且中医组中医症状积分、IL-5、IL-8、IL-10、TNF-α水平均低于同期对照组(P<0.05)。治疗2周内,中医组不良反应总发生率低于对照组(P<0.05)。用药结束后3个月内,两组患儿复发率比较差异无统计学意义(P>0.05)。结论:基于时间节律小柴胡汤加减治疗儿童CVA的临床疗效显著,能有效降低患儿气道炎症水平,且治疗过程中不良反应发生较小,值得临床应用推广。ObjectiveTo observe the influence of modified Xiaochaihu decoction based on time rhythm on airway inflammation levels in children with cough variant asthma(CVA)of lung qi deficiency syndrome.Methods 136 children with CVA of lung qi deficiency syndrome in our hospital were selected as the research subjects from May 2021 to May 2023,and were randomly divided into control group(n=68)and traditional Chinese medicine group(n=68)according to the random number table method.The control group was treated with Xiaoer Zhixiaoling tablets,while the traditional Chinese medicine group was given modified Xiaochaihu decoction combined with 24 solar terms.The clinical efficacy after 2 weeks of treatment and TCM symptoms scores and airway inflammation level before treatment and after 2 weeks of treatment were compared.The adverse reactions were counted in the two groups during treatment,and the recurrence of cough in the two groups within 3 months after the end of medication was observed.Results After 2 weeks of treatment,the efficacy in traditional Chinese medicine group was significantly higher than that in control group(P<0.05).The scores of TCM symptoms and levels of IL-5,IL-8,IL-10 and TNF-αin the two groups were reduced compared with those before treatment,and the scores and levels were lower in traditional Chinese medicine group than those in control group(P<0.05).Within 2 weeks of treatment,the total incidence rate of adverse reactions in traditional Chinese medicine group was lower compared with that in control group(P<0.05).There was no statistical difference in the recurrence rate between the two groups within 3 months after the end of medication(P>0.05).Conclusion Modified Xiaochaihu decoction based on time rhythm has a significant clinical efficacy in the treatment of CVA in children,and it can effectively reduce the airway inflammation level,and it has small adverse reactions during treatment.

关 键 词：时间节律 小柴胡汤 儿童 变异性咳嗽 气道炎症 

分 类 号：R256.11[医药卫生—中医内科学]