七味止痢散联合双歧杆菌四联活菌对腹腔镜胆囊切除术后腹泻患者大便性状及菌群的影响  

Effects of Qiwei Zhili Powder combined with tetralogy of viable bifidobacterium on stool property and floras in diarrhea patients after laparoscopic cholecystectomy

作　　者：刘燕 左小荣 王春艳 王毅 袁洁 刘思航 张民英 LIU Yan;ZUO Xiaorong;WANG Chunyan(Department of Gastroenterology,Xi'an Chang an District Hospital of Traditional Chinese Medicine,Xi'an Shanxi 710100,China;Internal Medicine of Traditional Chinese Medicine,Xi'an Chang an District Hospital of Traditional Chinese Medicine,Xi'an Shanxi 710100,China)

机构地区：[1]西安市长安区中医医院消化内科,陕西西安710100 [2]西安市长安区中医医院中医内科,陕西西安710100 [3]西安市长安区中医医院针灸理疗科,陕西西安710100 [4]西安市第九医院中医科,陕西西安710054

出　　处：《四川中医》2024年第9期152-155,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:探讨七味止痢散联合双歧杆菌四联活菌对腹腔镜胆囊切除术(LC)后腹泻患者大便性状及菌群的影响。方法:选取我院2020年6月~2022年6月106例LC术后腹泻患者,随机数字表法分为观察组(n=53)及对照组(n=53)。对照组予以双歧杆菌四联活菌,观察组在此基础联合七味止痢散。比较两组临床疗效、治疗前后大便性状、大便频率、肠道菌群、胃肠激素、炎症因子、不良反应。结果:观察组总有效率为94.33%(50/53),高于对照组的81.13%(43/53)(P<0.05);观察组治疗后大便性状评分及频率低于对照组(P<0.05);观察组治疗后肠球菌、大肠埃希菌数量低于对照组,乳酸杆菌、双歧杆菌数量高于对照组(P<0.05);观察组治疗后血清胃动素(MTL)、胃泌素(GAS)、血管活性肠肽(VIP)低于对照组(P<0.05);观察组治疗后血清白细胞介素(IL)-8、肿瘤坏死因子(TNF)-α、IL-6低于对照组(P<0.05)。结论:七味止痢散联合双歧杆菌四联活菌治疗LC术后腹泻的疗效确切,能改善患者的大便性状,降低大便频率,调节肠道菌群及胃肠激素,降低炎症因子水平。Objective:To explore the effects of Qiwei Zhili Powder combined with tetralogy of viable bifidobacterium on stool property and floras in diarrhea patients after laparoscopic cholecystectomy(LC).Methods A total of 106 patients with diarrhea after LC in the hospital were enrolled between June 2020 and June 2022.According to random number table method,they were divided into observation group(n=53)and control group(n=53).The control group was treated with tetralogy of viable bifidobacterium,while observation group was additionally treated with Qiwei Zhili Powder.The clinical curative effect,stool property,defecation frequency,intestinal floras,gastrointestinal hormones,inflammatory factors and adverse reactions were compared between the two groups before and after treatment.Results The total response rate of observation group was higher than that of control group[94.33%(50/53)vs 81.13%(43/53),P<0.05].After treatment,score of stool property and defecation frequency in observation group were lower than those in control group(P<0.05).After treatment,counts of Enterococcus and Escherichia coli in observation group were lower than those in control group,while counts of Lactobacillus and Bifidobacterium were higher than those in control group(P<0.05).After treatment,levels of serum motilin(MTL),gastrin(GAS)and vasoactive intestinal peptide(VIP)in observation group were lower than those in control group(P<0.05),and levels of serum interleukin(IL)-8,tumor necrosis factor(TNF)-αand IL-6 were also lower than those in control group(P<0.05).Conclusion:The curative effect of Qiwei Zhili Powder combined with tetralogy of viable bifidobacterium is significant on diarrhea after LC,which can improve stool property,reduce defecation frequency,regulate intestinal floras and gastrointestinal hormones,and relieve inflammatory factors.

关 键 词：腹腔镜胆囊切除术 七味止痢散 双歧杆菌四联活菌 腹泻 大便性状 肠道菌群 

分 类 号：R256.34[医药卫生—中医内科学]