金属纳米颗粒治疗白念珠菌感染研究进展  

Research progress on the treatment of Candida albicans infection by metal nanoparticles

作　　者：周爱琼 丁文静(综述)[2] 渠巍 莫非(审校)[1,3] ZHOU Aiqiong;DING Wenjing;QU Wei;MO Fei(School of Medical Laboratory,Guizhou Medical University,Guiyang,Guizhou 550000,China;Department of Clinical Laboratory,Guiyang Maternal and Child Health Care Hospital,Guiyang,Guizhou 550000,China;Department of Medical Affaires,the Affiliated Hospital of Guizhou Medical University,Guiyang,Guizhou 550000,China)

机构地区：[1]贵州医科大学医学检验学院,贵州贵阳550000 [2]贵阳市妇幼保健院检验科,贵州贵阳550000 [3]贵州医科大学附属医院医务处,贵州贵阳550000

出　　处：《国际检验医学杂志》2024年第18期2250-2257,2263,共9页International Journal of Laboratory Medicine

摘　　要：念珠菌病在全球范围内有很高的发病率及死亡率,其主要病原体是白念珠菌。目前,由于抗真菌药物存在毒性、耐药性、给药途径单一、价格昂贵等缺陷,使得念珠菌病治疗效果不理想。为了克服这一现状,具有抗真菌活性和运载抗真菌药物潜力的金属纳米颗粒被广泛研究。该文综述了金、银、铜、铁纳米颗粒的抗白念珠菌的作用机制及应用进展。与传统抗真菌药物比较,金属纳米颗粒通过多靶点机制发挥抗真菌作用,可最大限度地减少抗真菌耐药性的出现。虽然细胞毒性限制了金属纳米颗粒的应用,但绿色合成可降低金属纳米颗粒的细胞毒性并提高其抗菌性能等。Candidiasis has a high morbidity and mortality worldwide,and its main causative agent is Candida albicans.At present,the treatment effect of candidiasis is not ideal due to the shortcomings of antifungal drugs,such as toxicity,drug resistance,single route of administration,and high price.In order to overcome this situation,metal nanoparticles with antifungal activity and the potential to deliver antifungal drugs have been extensively studied.In this paper,the mechanism and application of gold,silver,copper and iron nanoparticles against Candida albicans are reviewed.Compared with traditional antifungal drugs,metal nanoparticles exert antifungal effects through a multi-target mechanism,which minimizes the emergence of antifungal resistance.Cytotoxicity limits the application of metal nanoparticles,but green synthesis can reduce the cytotoxicity of metal nanoparticles and improve antimicrobial properties.

关 键 词：金属纳米颗粒 抗真菌药 白念珠菌 

分 类 号：R446.5[医药卫生—诊断学] TB383[医药卫生—临床医学]