2型糖尿病患者糖化血红蛋白变异指数与亚动脉粥样硬化相关性分析  

Correlation between glycosylated hemoglobin variation index and sub atherosclerosis in patients with type 2 diabetes

作　　者：于瑞华 郑成然 徐美华 饶小胖 Yu ruihua;Zheng chengran;Xu meihua;rao Xiao Pang(Qingdao Chengyang District People's Hospital,Qingdao 266109,China)

机构地区：[1]青岛市城阳区人民医院内分泌科,山东青岛266109

出　　处：《青岛医药卫生》2024年第4期248-251,共4页Qingdao Medical Journal

摘　　要：目的探讨亚动脉粥样硬化与2型糖尿病(T2DM)患者糖化血红蛋白变异指数(HGI)的相关性及后者对其影响。方法纳入2018年2月~2021年1月收治青岛市城阳区人民医院内分泌科住院T2DM患者924例,采集临床资料和检测各项指标,依据三分位数法将研究对象HGI值分组为低HGI组、中HGI组和高HGI组,比较其指标差异并进行HGI与亚动脉粥样硬化相关性分析。结果三组收缩压(SBP)、糖化血红蛋白(HbA1c)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)、空腹C肽、颈动脉内膜中层厚度(CIMT)及亚动脉粥样硬化比例组间比较,有统计学差异(P<0.05)。高HGI组空腹C肽低于低HGI组及中HGI组,差异有统计学意义(P<0.05);HbA1c、尿白蛋白/尿肌酐(UACR)趋势高HGI组>中HGI组>低HGI组,差异有统计学意义(P<0.05);高HGI组的HbA1c、UACR、TC、TG、LDL-C、CIMT、亚动脉粥样硬化比例明显高于低HGI组,有统计学差异(P<0.05)。Logistic回归分析显示,HGI升高是亚动脉粥样硬化独立危险因素(OR=1.146,95%CI:1.013~1.426)。结论T2DM患者HGI与亚动脉粥样硬化相关,该指标可能有助于防治CVD发生发展。Objective To explore the correlation between sub atherosclerosis and glycosylated hemoglobin variation index(HGI)in patients with type 2 diabetes mellitus(T2DM)and the influence of the latter on it.Methods 924 inpatients with T2DM admitted to the Endocrinology Department of Chengyang District People's Hospital in Qingdao from February 2018 to January 2021 were included,collected clinical data and tested various indicators.The subjects were divided into low HGI group,medium HGI group and high HGI group according to the three quantile method.The differences of the indicators were compared and the correlation between HGI and sub-atherosclerosis was analyzed.Results There were significant differences in SBP,HbA1c,total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),fasting Cpeptide,carotid intima-media thickness(CIMT)and the proportion of sub-atherosclerosis among the three groups(P<0.05).The fasting C-peptide level in the high HGI group was significantly lower than that in the low HGI group and the medium HGI group(P<0.05);HbA1c,UACR trend:high HGI group>medium HGI group>low HGI group,the difference was statistically significant(P<0.05);Compared with the low HGI group,the CIMT,sub-atherosclerosis ratio,HbA1c,TC,UACR,TG,LDL-C in the high HGI group increased significantly(P<0.05).Logistic regression analysis showed that elevated HGI was an independent risk factor for sub-atherosclerosis(OR=1.146,95%CI:1.013-1.426).Conclusion HGI in T2DM patients is related to subatherosclerosis,which may be helpful to prevent and treat the occurrence and development of CVD.

关 键 词：糖化血红蛋白变异指数 糖化血红蛋白 颈动脉内中膜厚度 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]