达乌尔黄鼠的资源利用及模式动物化研究进展  

Progress in resource utilization and model animal research of Daurian ground squirrel

作　　者：邢昕 付有涛 刘新宇 杨明 XING Xin;FU Youtao;LIU Xinyu;YANG Ming(College of Life Science,Shenyang Normal University,Shenyang 110034,China)

机构地区：[1]沈阳师范大学生命科学学院,沈阳110034

出　　处：《中国实验动物学报》2024年第8期1052-1058,共7页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金(32071518,32301306,31500327)。

摘　　要：达乌尔黄鼠(Spermophilus dauricus)是我国研究冬眠的主要动物模型,具有适应极端低体温、低代谢以及抗缺血-再灌注损伤、抗废用性肌萎缩等生理特点,并且具有独特的体脂积累和耐受机制。这些生理特征在临床及航天领域的应用中具有重要借鉴意义和研究价值。达乌尔黄鼠的模式动物化有助于对上述生理机制进行深入探究。本文综述了达乌尔黄鼠的生物学特征及其在临床与航天应用的研究价值,介绍了目前国内达乌尔黄鼠在实验室和野外的繁殖和实验动物化的进展,展望了将该物种模式动物化的前景及其关注点。The Daurian ground squirrel(Spermophilus dauricus)is the main animal model used for hibernation research in China.This species has many striking physiological adaptive characteristics,such as an adaptation to extreme hypothermia,a low metabolism,resistance to ischemia-reperfusion injury,disuse muscular atrophy,and unique mechanisms of body fat accumulation.These characteristics make the Daurian ground squirrel a unique and significant reference model with research value in clinical and space flight applications.The application of the Daurian ground squirrel as a model animal will help us to further explore the physiological mechanisms mentioned above.This review summarizes the biological characteristics and research values of Daurian ground squirrels in clinical and space flight applications.We also introduce the current progress made in the breeding and experimental animalization of Daurian ground squirrels for laboratory and field research,and advise on precautions that need to be considered during the experimental animalization of this species.

关 键 词：达乌尔黄鼠 冬眠 实验动物 

分 类 号：Q95-33[生物学—动物学]