Assessing the efficacy and safety of gemcitabine-induced thrombocytopenia/neutropenia and thrombocytopenia interventions in zebrafish  

作　　者：Jialong Deng Ziyuan Zhou Wangjun Liao Qing Lin Yiyue Zhang 

机构地区：[1]Innovation Centre of Ministry of Education for Development and Diseases,School of Medicine,South China University of Technology,Guangzhou,Guangdong 510006,China [2]Department of Hematology,The Sixth Affiliated Hospital,School of Medicine,South China University of Technology,Foshan,Guangdong 528200,China [3]Department of Oncology,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong 510515,China

出　　处：《Journal of Genetics and Genomics》2024年第9期970-973,共4页遗传学报（英文版）

基　　金：supported by Guangdong Basic and Applied Basic Research Foundation(2024B1515040019);the National Natural Science Foundation of China(32161160326,32270875,and 32370874);the National Key R&D Program of China(2023YFA1800100);the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme(2019).

摘　　要：Cancer is a major global health issue;in 2020,there were 19.29 million new cancer cases and 9.96 million cancer deaths worldwide(Siegel et al.,2023).Despite ongoing research,chemotherapy remains the primary treatment due to its broad anti-cancer effects(Marra and Curigliano,2021).However,intravenous chemotherapeutic drugs commonly induce hematotoxicity,necessitating dose adjustments or treatment delays.Chemotherapy-induced thrombocytopenia(CIT)and neutropenia(CIN)are the primary manifestations of chemotherapy-induced hematotoxicity,which requires intervention due to the heightened risk of bleeding and infection(Blayney and Schwartzberg,2022).Currently,there are no FDA-approved treatments for CIT(Song and Al-Samkari,2023).While a CIT mouse model using 5-FU has been developed for drug evaluation(Shin et al.,2023),it lacks a comprehensive hematotoxicity assessment and the benefits of high throughput,cost-effectiveness,and visibility.Therefore,it is urgent to develop a high-throughput CIT model for risk assessment and safer chemotherapy strategies with clinical potential.

关 键 词：chemotherapy treatment VISIBILITY 

分 类 号：Q95[生物学—动物学]