胃滞留给药系统的研究进展  

Advances in gastric retention drug delivery system

作　　者：吴艳梅 刘凤雪 宫苹 陈宁[1] 郑威[1] WU Yan-mei;LIU Feng-xue;GONG Ping;CHEN Ning;ZHENG Wei(Harbin University of Commerce,Harbin 150076,China)

机构地区：[1]哈尔滨商业大学,黑龙江哈尔滨150076

出　　处：《药学学报》2024年第9期2499-2508,共10页Acta Pharmaceutica Sinica

基　　金：哈尔滨商业大学“青年科研创新人才”项目(2023-KYYWF-1037).

摘　　要：传统的口服给药方式,由于胃排空速度快和胃肠道转运时间短,导致药物在完全释放之前被排出,降低了药物的生物利用度。为了保持药物在体内的有效浓度并发挥其最佳疗效,通常需要增加给药次数。相比较而言,胃滞留给药系统(gastric retention drugdelivery system,GRDDS)作为一种创新的给药方法,延长药物在胃中的滞留时间,减少了对胃肠道的刺激性,提高了药物的生物利用度,减少了患者的服药次数,增强了患者的治疗依从性。近几年来,国内外在GRDDS方面进行了广泛的研究,本文总结了GRDDS研究进展,对其上市情况、类型及体内外评价方法等方面进行综述。The conventional oral drug delivery frequently results in the drug elimination before its complete release due to rapid gastric emptying and short gastrointestinal transport time,thus reducing the bioavailability of drug.In order to maintain an effective concentration of drug in the body and maximize its optimal efficacy,the frequency of administrations often needs to be increased.By contrast,gastric retention drug delivery system(GRDDS),as an innovative method of drug delivery,prolongs the retention time of the drug in the stomach and reduces irritation to the gastrointestinal tract.Consequently,it enhances the bioavailability of drug,reduces dosing frequency for patients and improves treatment adherence.In recent years,domestic and foreign studies have been conducted on gastric retention drug delivery systems.Here,we provide a comprehensive overview of the relevant literature published in recent years,examining their current marketing status,various types,as well as in vivo and in vitro evaluationmethods.

关 键 词：胃滞留给药系统 胃滞留时间 生物利用度 依从性 体内外评价 

分 类 号：R943[医药卫生—药剂学]