中麻黄二氯甲烷萃取部位化学成分研究  

Chemical constituents of dichloromethane extract from the stems of Ephedra intermedia

作　　者：范锡玲 曹彦刚 郑晓珂[1,2,3] 王振中 肖伟 冯卫生 FAN Xi-ling;CAO Yan-gang;ZHENG Xiao-ke;WANG Zhen-zhong;XIAO Wei;FENG Wei-sheng(Henan University of Chinese Medicine,Zhengzhou 450046,China;Engineering and Technology Center for Chinese Medicine Development of Henan Province,Zhengzhou 450046,China;Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan Province and Ministry of Education of China,Zhengzhou 450046,China;State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture,Lianyungang 222001,China)

机构地区：[1]河南中医药大学,河南郑州450046 [2]河南省中药开发工程技术研究中心,河南郑州450046 [3]呼吸疾病中医药防治省部共建协同创新中心,河南郑州450046 [4]中药制药过程控制与智能制造技术全国重点实验室,江苏连云港222001

出　　处：《药学学报》2024年第9期2574-2580,共7页Acta Pharmaceutica Sinica

基　　金：国家重点研发计划-中医药现代化研究重点专项(2019YFC1708800)

摘　　要：采用各种柱色谱分离技术对中麻黄二氯甲烷萃取部位化学成分进行分离纯化得到10个化合物,并通过波谱学方法(MS和NMR)对其进行结构鉴定,分别为1-allyl-3,4-dimethoxy-benzene-5-O-β-D-glucopyranoside(1)、lyoniresinol(2)、开环异落叶松脂素(3)4,3',4'-trihydroxy-3-methoxylignan-9,9'-diyldiacetate(4)dehydroconiferyl alcohol(5)、isocubebin(6)、balanophonin B(7)、sesquipinsapol B(8)、crataegifin A(9)以及1-(2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydrobenzofuran-5-yl)ethan-1-one(10),其中化合物1为新化合物,化合物2~10为木脂素类化合物,且均为首次从该植物中分离得到,化合物3、4、8具有潜在的抗哮喘活性。Ten compounds were isolated and purified from the dichloromethane extract of stems of Ephedra intermedia by various chromatographic methods.Based on the analysis of physicochemical properties and spectral data,the structures of the ten compounds were identified as 1-allyl-3,4-dimethoxy-benzene-5-O-β-D-glucopyranoside(1),lyoniresinol(2),secoisolariciresinol(3),4,3',4'-trihydroxy-3-methoxylignan-9,9'-diyldiacetate(4),dehydroconiferyl alcohol(5),isocubebin(6),balanophonin B(7),sesquipinsapol B(8),crataegifin A(9),1-(2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydrobenzofuran-5-yl)ethan-1-one(10).Compound 1 is a new compound,named as 1-allyl-3,4-dimethhoxy-benzene-5-O-β-D-glucopyranosyl,compounds 2-10 are lignans and isolated from this plant for the first time.Compound 3,4,8 possess potentially anti-asthmatic activities.

关 键 词：中麻黄 化学成分 β-氨基己糖苷酶释放率 

分 类 号：R284[医药卫生—中药学]