弱耦合导致的再入性心律失常研究  

Study on Reentrant Arrhythmia Caused by Weak Coupling

作　　者：韦智杰 莫玉香[1,2] 林榕梅 兰孝克 唐国宁 Zhijie WEI;Yuxiang MO;Rongmei LIN;Xiaoke LAN;Guoning TANG(College of Physical Science and Technology,Guangxi Normal University,Guilin,Guangxi 541004,China;Guangxi Key Laboratory of Nuclear Physics and Technology,Guangxi Normal University,Guilin,Guangxi 541004,China)

机构地区：[1]广西师范大学物理科学与技术学院,广西桂林541004 [2]广西核物理与核技术重点实验室,广西桂林541004

出　　处：《计算物理》2024年第5期670-679,共10页Chinese Journal of Computational Physics

基　　金：国家自然科学基金(11565005);中央引导地方科技发展资金(桂科ZY22096024);广西自然科学基金(2018GXNSFBA050028)资助项目。

摘　　要：采用Luo-Rudy相I心脏模型研究点波源产生的波在一维、二维弱耦合心肌组织中的传播,观察到弱耦合会导致波传播速度减小;当心肌组织出现大的耦合强度梯度时,弱耦合会导致波传播受阻和心肌细胞出现早期后除极化;当心肌细胞之间耦合强度足够低时,观察到心肌组织会出现波的环形运动和复杂的波传播现象。此外通过构造两种不同耦合结构的二维心肌组织,研究平面波在二维弱耦合心肌组织中的传播,结果发现:平面波在这两种心肌组织中传播时都可自发产生螺旋波,提高细胞之间耦合强度可有效阻止波的环形运动和螺旋波的自发产生。进一步分析了产生上述现象的物理机制。The Luo Rudy phase I heart model is used in this paper to study the propagation of waves generated by point wave sources in one-and two-dimensional weakly coupled myocardial tissues.It is observed that the weak coupling can lead to the reduction of the wave propagation speed.When there is a large coupling intensity gradient in the myocardial tissue,weak coupling can lead to the frustration of wave propagation and early afterdepolarization showed by cardiomyocytes.When the coupling intensity between cardiomyocytes is low enough,circular motion of wave and complex wave propagation can be observed in myocardial tissues.In addition,we also study the propagation of planar wave in two-dimensional weakly coupled myocardial tissues by constructing two different two-dimensional myocardial tissues with different coupling structures.We find that spiral waves can be spontaneously generated when plane wave propagates in the two myocardial tissues.Increasing the coupling intensity between cells can effectively prevent the circus movement of wave and the spontaneous generation of spiral wave.The physical mechanism of the above phenomenon is analyzed in this paper.

关 键 词：弱耦合 心肌缺血 螺旋波 心律失常 

分 类 号：O411.3[理学—理论物理]