非HLA抗体检测方法研究进展  

Testing methods of non-human leukocyte antigen antibodies

作　　者：尚丽红 武小桐 李宁 石韶华 王志华 朱琳茹 周华 Shang Lihong;Wu Xiaotong;Li Ning;Shi Shaohua;Wang Zhihua;Zhu Linru;Zhou Hua(Laboratory of Kidney Transplantation Center,Shangxi Second People′s Hospital,Taiyuan 030012,China;Kidney Transplantation Center,Shangxi Second People′s Hospital,Taiyuan 030012,China)

机构地区：[1]山西省第二人民医院肾移植中心实验室,太原030012 [2]山西省第二人民医院肾移植中心

出　　处：《中华移植杂志（电子版）》2024年第1期60-64,共5页Chinese Journal of Transplantation(Electronic Edition)

基　　金：山西省卫生健康委员会"四个一批"科技兴医创新计划重点攻关专项资助项目(2021XM24)。

摘　　要：HLA抗体一直是器官移植抗体介导排斥反应(AMR)预防和治疗的焦点,然而来自临床和基础研究的证据表明,非HLA抗体也参与AMR或AMR样组织学损伤。已有多种检测非HLA抗体的方法,可靠和灵敏的检测方法有助于推动非HLA抗体检测在器官移植中的应用,改善临床结局。本文就非HLA抗体检测方法的研究进展进行综述。Human leukocyte antigen (HLA) antibodies have been the focus in the prevention and treatment of antibody-mediated rejection (AMR) in organ transplantation. However, evidence from the clinic and basic studies has shown that non-HLA antibodies are associated with AMR or AMR like histologic lesions. There have been many methods to test non-HLA antibodies. Reliable and sensitive testing methods can help promote the application of non-HLA antibody detection in organ transplantation and improve clinical outcomes. This article review the research progress on testing methods of non-HLA antibodies.

关 键 词：非HLA抗体 器官移植 抗体介导排斥反应 抗体介导排斥反应样组织损伤 

分 类 号：R699.2[医药卫生—泌尿科学]