实体器官移植后难治性/耐药性巨细胞病毒感染诊疗进展  

Progression in diagnosis and treatment of refractory/resistant cytomegalovirus infection after solid organ transplantation

作　　者：巨春蓉[1] 门同义 薛武军[3] Chunrong;Men Tongyi;Xue Wujun(The First Afiliated Hospital of Guangzhou Medical University,Guangzhou Institute of Respiratory Health,National Key Laboratory of Respiratory Disease,National Clinical Medical Research Center of Respiratory Disease,Guangzhou 510120,China;Department of Urinary Surgery,the Affliated Hospital of Inner Mongolia Medical University,Hohhot 750306,China;Department of Kidney Transplantation,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]广州医科大学附属第一医院、广州呼吸健康研究院呼吸疾病国家重点实验室、国家呼吸疾病临床医学研究中心,510120 [2]内蒙古医科大学附属医院泌尿外科,呼和浩特750306 [3]西安交通大学附属第一医院肾移植科,710061

出　　处：《中华移植杂志（电子版）》2024年第2期86-92,共7页Chinese Journal of Transplantation(Electronic Edition)

基　　金：呼吸疾病国家重点实验室/广州呼吸健康研究院/国家呼吸中心临床自主探索项目(SKLRHQN20205);广东省钟南山医学基金会(ZNSA-2020013);广东省自然科学基金(2022A1515012216);广州市临床特色技术项目(2023C—TS10);广州医科大学科研能力提升计划重大临床研究项目(GMUCR2024-01007)

摘　　要：随着我国实体器官移植(SOT)事业的飞速发展,巨细胞病毒(CMV)感染的发病人数日益增多。其中,耐药性和难治性CMV感染的发病率也逐渐升高,导致SOT受者的死亡率显著增加,值得临床高度关注。随着新的诊断技术出现和新药的研发上市,难治性/耐药性CMV感染的诊疗不断发展。本文总结了SOT受者难治性CMV感染的诊治新进展,包括难治性/耐药性CMV感染的定义、诊断以及治疗策略,旨在为预防和治疗SOT后难治性/耐药性CMV感染提供参考。With the rapid development of solid organ transplantation(SOT)in China,the number of people infected with cytomegalovirus(CMV)is increasing.The incidence rate of resistant CMV and refractory CMV infection is also increasing,leads to the mortality increase significantly,which require clinical attention.Along with improvement of the new diagnostic technologies and new drugs,the diagnosis and treatment of refractory/resistant CMV infection continue to improve.This review summarizes the new progress in the diagnosis and treatment strategies on refractory CMV infection in SOT recipients,including the definition,the diagnosis and treatment strategies.The article is aimed to provide references for prevention and treatment of refractory/drug resistant CMV infection in organ transplant recipients.

关 键 词：实体器官移植 巨细胞病毒 难治性 耐药性 

分 类 号：R617[医药卫生—外科学]