聚(丙交酯-己内酯)的制备及性能  

Preparation and Properties of Poly(lactate-co-ε-caprolactone)Composites

作　　者：尹琪琦 陈荣盈 王昱 丁亚北 李宏利 Qiqi Yin;Rongying Chen;Yu Wang;Yabei Ding;Hongli Li(National and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials,School of Chemistry and Environment,Yunnan Minzu University,Kunming 650500,China;Hubei China Tobacco Cigarette Material Factory,Wuhan 430051,China)

机构地区：[1]云南民族大学化学与环境学院生物基材料绿色制备技术国家地方联合工程研究中心,云南昆明650500 [2]湖北中烟卷烟材料厂,湖北武汉430051

出　　处：《高分子材料科学与工程》2024年第7期18-26,共9页Polymer Materials Science & Engineering

基　　金：云南省基础研究专项(202301AT070018);云南省青年拔尖人才万人计划(YNWR-QNBJ-2019-094)。

摘　　要：以L-丙交酯(L-LA)与ε-己内酯(ε-CL)为原料,制备了3种不同比例的聚(丙交酯-己内酯)共聚物(PLCL),通过螺杆挤出将其加工成型。核磁共振氢谱和红外光谱结果表明,制备的PLCL结构与理论产物结构一致,凝胶渗透色谱结果显示3种不同比例的PLCL相对分子质量均在10万以上。拉伸性能及接触角测量结果表明,材料结构牢固且为亲水性,力学性能较好,并且通过与现有非降解骨科材料比较,能达到应用要求。热分析和降解实验结果显示,随着L-丙交酯的含量增多,PLCL的热稳定性降低,降解速率变快。细胞毒性研究表明,3种材料的细胞存活率均超过100%,具有一定增殖作用,显示出其在骨科材料中的应用前景。Using L-Lactide(L-LA)andε-caprolactone(ε-CL)as raw materials,three kinds of poly(lactide caprolactone)copolymers(PLCL)with different proportions were prepared by screw extrusion.The results of hydrogen NMR and infrared spectroscopy show that the structure of PLCL is consistent with that of the theoretical products.The molecular weight of PLCL with three different proportions is more than 10000.The results of tensile properties and contact angle measurement show that the material is strong,hydrophilic and has good mechanical properties,and can meet the application requirements by comparing with existing non-degradable orthopedic materials.The results of thermal analysis and degradation experiments show that the thermal stability of PLCL decreases and degradation rate increases with the increase of L-lactide content.The cytotoxicity study shows that the survival rate of the three materials is more than 100%,and they have a certain proliferation effect,which shows their application prospect in orthopedic materials.

关 键 词：L-丙交酯 Ε-己内酯 聚(丙交酯-己内酯) 共聚 骨科材料 

分 类 号：TQ323.4[化学工程—合成树脂塑料工业]