Hemostatic mechanism of Jianpi Yiqi Shexue decoction(健脾益气摄血方) in treatment of immune thrombocytopenia  

作　　者：LI Ruibai CHEN Ke MA Wei ZHANG Yayue HOU Li CHEN Xinyi 

机构地区：[1]Department of Oncology and Hemotology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100091,China [2]Department of Hemotology,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China

出　　处：《Journal of Traditional Chinese Medicine》2024年第3期537-544,共8页中医杂志（英文版）

基　　金：National Key Basic Research and Development Program (973 Program) Project:the Therapeutic Mechanism and Pattern of Spleen Based Treatment for Thrombocytopenic Purpura Caused by Spleen Failure to Regulate Blood Flow (2013CB531705)。

摘　　要：OBJECTIVE: To explore the early hemostatic mechanism of Jianpi Yiqi Shexue decoction(健脾益气摄血方, JYSD) in treating immune thrombocytopathy(ITP), based on the functional homeostasis of brain-intestine axis and blood neurotransmitter METHODS: Non-drug treatment cases: Healthy volunteers were selected as normal control group and compared with patients with dysfunctional uterine bleeding, gastrointestinal tumors with bleeding and ITP, to detect the changes of blood 5-hydroxytryptamine(5-HT), β-endorphin(β-EP), vasoactive intestinal peptide(VIP) and compare the changes of blood neurotransmitters in patients with different disease symptoms. Drug treatment cases: According to the randomized controlled multicenter clinical trial, 272 ITP patients were randomly divided into three groups: treatment group(JYSD) combined group(JYSD + Prednisone) control group(Prednisone). The changes of blood neurotransmitter(5-HT, β-EP, VIP) before and after treatment were detected on the basis of peripheral blood platelet(PLT) and grade score. RESULTS: Non-drug treatment cases: compared with the normal control group, the 5-HT level was higher, and the VIP and β-EP levels were both lower in the ITP group(P < 0.001), and the 5-HT, VIP and β-EP levels in the Gastrointestinal tumors with bleeding group were also lower compared with the normal control group(P < 0.05, 0.001). Drug treatment cases: The PLT grading scores of the combination group and the control group after treatment were lower than that before treatment(P < 0.05, 0.001). The PLT grading score of the 3 groups were compared in pairs after treatment: the combination group was the lowest among the 3 groups, which was better than the treatment group, but no better than the control group(vs the treatment group, P = 0.005, vs the control group, P = 0.709). The statistical results of full analysis set(FAS) and per protocol set(PPS) were consistent. The bleeding symptom scores of the treatment and combination groups began to drop 7 d after treatment, and kept dropping 14 d

关 键 词：immune thrombocytopenic purpura brain-gut axis vasoactive intestinal peptide BETA-ENDORPHIN SEROTONIN 

分 类 号：R259[医药卫生—中西医结合]