Distribution of Traditional Chinese Medicine syndromes in diabetic kidney disease chronic kidney disease 1-5: a correlation study  

作　　者：LI Shuang DUAN Shuwei DONG Zheyi QU Yilun LUO Yayong KE Jianghua WANG Conghui PENG Yangzhi ZHOU Xuefeng CHEN Xiangmei 

机构地区：[1]Department of Nephrology,First Medical Center of Chinese PLA General Hospital,Nephrology Institute of the Chinese People's Liberation Army,National Key Laboratory of Kidney Diseases,National Clinical Research Center for Kidney Diseases,Beijing Key Laboratory of Kidney Disease Research,Beijing 100853,China [2]School of Clinical Medicine,Guangdong Pharmaceutical University,juangzhou510006,China [3]Basic Medical College,Chengdu University of Traditional Chinese Medicine,Chengdu610075,China

出　　处：《Journal of Traditional Chinese Medicine》2024年第3期572-580,共9页中医杂志（英文版）

基　　金：the Beijing Science and Technology Plan Project:Study on Multidimensional Precise Diagnosis and Treatment Technology and Clinical Transformation of Type 2 Diabetic Nephropathy (No. Z221100007422121);the Beijing Science and Technology Plan Project:Correlation between Clinical Phenotype and Pathological Diagnosis of Type 2 Diabetic Nephropathy (D171100002817002);the State Key Research and Development Program:Study on the Core Pathogenesis and Clinical Evolution of Damp-heat Symptom in Diabetic Nephropathy (2018YFC1704203);National Key R&D Program of China (2018YFC1704200);Natural Science Foundation of China:Mechanism of Organ Immune Injury and Basic Research of Integrated Traditional Chinese and Western Medicine Diagnosis and Treatment (No. 32141005)。

摘　　要：OBJECTIVE: To analyze the distribution of Traditional Chinese medicine(TCM) syndromes in patients with diabetic kidney disease(DKD) and its related factors.METHODS: We enrolled 435 patients with DKD, who were not undergoing dialysis, admitted to the Department of Nephrology, First Medical Center, Chinese PLA General Hospital from April 2020 to August 2021.Analysis of their TCM syndromes and related factors was carried out.RESULTS: The 435 patients included 109, 117, 86, and 123 chronic kidney disease(CKD) 1-2, CKD3, CKD4, and CKD5 cases, respectively. With the progression of CKD1-5, the proportion of Yin deficiency and dry heat syndrome,and that of Qi and Yin deficiency syndrome showed a downward trend, whereas the proportion of spleen-kidney Yang deficiency, blood deficiency, blood stasis, water stagnation, and phlegm turbidity syndromes showed an upward trend;the differences were statistically significant(P < 0.05). Multivariate logistic regression analysis showed that Yin deficiency and dry heat syndrome was positively correlated with hemoglobin [odds ratio(OR) =1.022, P = 0.005], albumin(OR = 1.058, P = 0.006), and estimated glomerular filtration rate(eGFR)(OR = 1.020,P < 0.001) but negatively correlated with male sex(OR =0.277, P = 0.004). Qi and Yin deficiency syndrome was positively correlated with albumin(OR = 1.056, P < 0.001)and eGFR(OR = 1.008, P = 0.022) but negatively correlated with age(OR = 0.977, P = 0.023). Liver-kidney Yin deficiency syndrome was positively correlated with age(OR = 1.028, P = 0.021) and glycosylated hemoglobin(OR = 1.223, P = 0.007) but negatively correlated with total cholesterol(OR = 0.792, P = 0.006).Spleen-kidney Yang deficiency syndrome was negatively correlated with hemoglobin(OR = 0.977, P < 0.001),albumin(OR = 0.891, P < 0.001), and eGFR(OR = 0.978,P < 0.001) but positively correlated with high density lipoprotein(OR = 3.376, P = 0.001). CONCLUSION: With CKD1-5 progression, TCM syndromes changed from Yin deficiency and dry heat syndrome to syndrome of deficiency of both

关 键 词：diabetic nephropathies syndrome and complex HEMOGLOBINS ALBUMINS glomerular filtration rate correlation of data 

分 类 号：R259[医药卫生—中西医结合] R277.5[医药卫生—中医内科学]