Animal models of tendon calcification:Past,present,and future  

作　　者：Ruichen Li Canhao Lai Hong Luo Yujian Lan Xinfang Duan Dingsu Bao Zhipeng Hou Huan Liu Shijie Fu 

机构地区：[1]Department of Bone and Joint,The Affiliated Traditional Chinese Medicine Hospital,Southwest Medical University,Luzhou,China [2]Chengdu University of Traditional Chinese Medicine,Chengdu,China

出　　处：《Animal Models and Experimental Medicine》2024年第4期471-483,共13页动物模型与实验医学（英文）

基　　金：the Science and Technology Innovation Cooperation Special Programme of Sichuan Province,Grant/Award Number:2022YFS0609-C1;Industry-University-Research Cooperation Foundation,Grant/Award Number:2021CXYZ01;Luzhou Science and Technology Plan Project,Grant/Award Number:2021-SYF-25;China Postdoctoral Science Foundation,Grant/Award Number:2023M732927;Scientific Research Project of Southwest Medical University,Grant/Award Number:2021ZKMS051 and 2022QN018。

摘　　要：Tendon calcification is a common clinical condition that frequently occurs as a complication after tendon injury and surgery,or as an expression of fibrodysplasia ossificans progressiva.This condition can be referred to by various names in clinical practice and literature,including tendon ossification,tendon mineralization,heterotopic ossification,and calcific tendonitis.The exact pathogenesis of tendon calcification remains uncertain,but current mainstream research suggests that calcification is mostly cell mediated.To further elucidate the pathogenesis of tendon calcification and to better simulate the overall process,selecting appropriate experimental animal models is important.Numerous animal models have been utilized in various clinical studies,each with its own set of advantages and limitations.In this review,we have discussed the advancements made in research on animal models of tendon calcification,with a focus on the selection of experimental animals,the sites of injury in these models,and the methods employed for modeling.

关 键 词：animal models review tendon calcification 

分 类 号：R686.1[医药卫生—骨科学] R-332[医药卫生—外科学]