环状RNA在心力衰竭中的研究进展及现状  

Research progress and current status of circular RNA in heart failure

作　　者：杨钦 杜冰鑫 杨晔颖 李芮 田进伟 刘惠彬[1,2] YANG Qin;DU Bingxin;YANG Yeying;LI Rui;TIAN Jinwei;LIU Huibin(Department of Pharmacy,the Second Affiliated Hospital of Harbin Medical University;Heilongjiang Provincial Key La-boratory of Panvascular Disease;Department of Cardiology,the Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150086,China)

机构地区：[1]哈尔滨医科大学附属第二医院药学部 [2]黑龙江省泛血管疾病重点实验室 [3]哈尔滨医科大学附属第二医院心内科,黑龙江省哈尔滨市150086

出　　处：《中国动脉硬化杂志》2024年第9期737-746,共10页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(U21A20391);黑龙江省自然科学基金项目(ZD2023H005)。

摘　　要：环状RNA(circRNA)是一类新型的内源性非编码RNA,具有复杂的生物学功能,参与多种生理及病理过程。circRNA的结构相对稳定且组织表达具有时序性和特异性,因而成为近期生物医学研究热点之一。心力衰竭(HF)多由原发性心肌损害及心脏负荷过重导致的心室充盈和/或射血功能低下而引起的心脏病变,即心脏泵血无法满足全身组织代谢所需,是众多心脏疾病的终末阶段。研究发现circRNA可能与HF进程中的心肌细胞肥大、心肌细胞凋亡、自噬以及心肌纤维化等密切相关,其在HF发生发展中具有重要调节作用。该文将从circRNA的形成分类、功能形式及在HF中的作用和机制进行综述,为预防和治疗HF提供新思路。Circular RNA(circRNA)is a novel class of endogenous non-coding RNA with complex biological functions,participating in various physiological and pathological processes.Due to their relatively stable stucture and tissuespecific and temporal expression patterns,circRNA have become a recent focus of biomedical research.Heart failure(HF)is characterized by impaired ventricular filling and/or ejection function caused by primary myocardial injury and cardiac overload,leading to the inability of the heart to meet the metabolic demands of the body’s tissues.It is the end stage of numerous cardiac diseases.Studies have found that circRNA may play a crucial regulatory role in the progression of HF,particularly in cardiomyocyte hypertrophy,cardiomyocyte apoptosis,autophagy and myocardial fibrosis.This review summarizes the formation,classification,functional forms,and roles in HF of circRNA,aiming to provide new insights for the prevention and treatment of HF.

关 键 词：环状RNA 心力衰竭 心肌纤维化 心肌肥大 细胞凋亡 自噬 

分 类 号：R54[医药卫生—心血管疾病]