中医药调控糖尿病心肌病中细胞焦亡的研究进展  

The research progress of Traditional Chinese Medicine regulating pyroptosis in dia-betes cardiomyopathy

作　　者：张楠 贾云柱 田纪祥[2] 王云[2] ZHANG Nan;JIA Yunzhu;TIAN Jixiang;WANG Yun(Qingdao Special Service Recuperation Center of the PLA Navy,Qingdao,Shandong 266000,China;Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国人民解放军海军青岛特勤疗养中心,山东省青岛市266000 [2]中国中医科学院中药研究所,北京市100700

出　　处：《中国动脉硬化杂志》2024年第9期813-820,828,共9页Chinese Journal of Arteriosclerosis

基　　金：国家科技重大专项(2019ZX09201-005)。

摘　　要：糖尿病心肌病(DCM)是在糖尿病糖脂代谢紊乱情况下,心肌发生结构性损伤及功能障碍的一种心血管疾病,主要病理特征是心室肥大、心肌重构及心肌细胞死亡,诱发心力衰竭。DCM已成为糖尿病患者死亡的主要原因之一。而由炎症小体介导的细胞焦亡作为一种促炎性的程序性细胞死亡方式,其过度激活被认为是慢性炎症的重要驱动力。最近发现细胞焦亡的过度激活推动了DCM的病程,成了连接糖尿病糖脂代谢紊乱与心肌损伤的枢纽。随着越来越多中医药调控细胞焦亡的作用被发现,中医药通过调控细胞焦亡信号通路或蛋白表达,影响DCM的发生发展,成为糖尿病心肌保护策略的研究热点。本文就细胞焦亡在DCM中的作用机制以及中药单体/活性成分和中药复方通过调控细胞焦亡过程在DCM中的研究进展进行综述,以期为DCM的临床研究和治疗提供新思路和新靶点。Diabetes cardiomyopathy(DCM)is a cardiovascular disease with structural damage and dysfunction of myocardium under the condition of glucose and lipid metabolism disorder in diabetes.The main pathological characteristics are ventricular hypertrophy,myocardial remodeling and cardiomyocyte death,which induce heart failure.DCM has become one of the main causes of death in patients with diabetes.As a pro-inflammatory programmed cell death pathway,pyroptosis mediated by inflammasomes is considered an important driver of chronic inflammation due to its excessive activation.Recently,it was found that the over activation of pyroptosis promoted the course of DCM and became the hub connecting the disorder of glucose and lipid metabolism in diabetes and myocardial injury.With the discovery of more and more roles of Traditional Chinese Medicine(TCM)in regulating pyroptosis,TCM affects the occurrence and development of DCM by regulating pyroptosis or protein expression,which has become a research hotspot of myocardial protection strategies in diabetes.This article reviews the mechanism of pyroptosis in DCM and the research progress of TCM monomers and compound prescriptions in regulating the process of pyroptosis in DCM,in order to provide new ideas and targets for clinical research and treatment of DCM.

关 键 词：糖尿病心肌病 细胞焦亡 NOD样受体热蛋白结构域相关蛋白3 中医药治疗 

分 类 号：R5[医药卫生—内科学]