CXCL12/MIF-CXCR4生物轴在治疗动脉粥样硬化应用中的研究进展  

Advances in the CXCL12/MIF-CXCR4 bioaxis for therapeutic atherosclerosis appli-cations

作　　者：梁子舜 蔡晶 乔彤 LIANG Zishun;CAI Jing;QIAO Tong(Department of Vascular Surgery,Nanjing Drum Tower Hospital Clinical College of Nanjing University of Traditional Chinese Medicine,Nanjing,Jiangsu 210008,China;Department of Vascular Surgery,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing,Jiangsu 210008,China)

机构地区：[1]南京中医药大学鼓楼临床医学院血管外科,江苏省南京市210008 [2]南京大学医学院附属鼓楼医院血管外科,江苏省南京市210008

出　　处：《中国动脉硬化杂志》2024年第9期821-828,共8页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金青年基金项目(82200543);江苏省卫生健康委医学科研项目(ZD2021056)。

摘　　要：动脉粥样硬化(As)是世界范围内死亡率和发病率高的主要原因之一。趋化因子及其受体参与As的发病机制。CXC趋化因子配体12(CXCL12)是趋化因子家族的成员,巨噬细胞迁移抑制因子(MIF)是趋化因子样功能趋化因子,CXCL12和MIF共同通过CXC趋化因子受体4(CXCR4)在As中发挥着重要的作用。CXCL12-CXCR4生物轴是一条重要的趋化因子/趋化因子受体轴,能够调控细胞增殖、动员、分化、归巢和趋化等多种生物学行为,大量研究发现其广泛影响着与As相关的多种细胞,与As斑块的形成、发展密切相关。因此,CXCL12/MIF-CXCR4生物轴有望成为更加精确的As治疗靶点,调控CXCL12/MIF-CXCR4生物轴策略为As的防治提供新的思路。Atherosclerosis(As)is one of the major causes of high mortality and morbidity worldwide.Chemokines and their receptors are involved in the pathogenesis of As.CXC chemokine ligand 12(CXCL12)is a member of the chemokine family,and macrophage migration inhibition factor(MIF)is a chemokine like functional chemokine,CXCL12 and MIF together play important roles in As through CXC chemokine receptor 4(CXCR4).The CXCL12-CXCR4 bioaxis is an important chemokine/chemokine receptor axis that can regulate various biological behaviors such as cell proliferation,mobilization,differentiation,homing,and chemotaxis.Numerous studies have found that it widely affects various cells related to As and is closely related to the formation and development of As plaques.Therefore,the CXCL12/MIF-CXCR4 bioaxis is expected to become a more precise target for As treatment,and regulating the CXCL12/MIF-CXCR4 bioaxis strategy provides new ideas for the prevention and treatment of As.

关 键 词：CXCL12/MIF-CXCR4生物轴 巨噬细胞迁移抑制因子 动脉粥样硬化 

分 类 号：R5[医药卫生—内科学]