现代组学技术在中药防治糖脂代谢紊乱机制探索中的应用  

Application of Modern Omics Technology in Exploring the Mechanism of Preventing and Treating Glucose and Lipid Metabolism Disorders in TCM

作　　者：魏佳华 方心怡 苗润宇 张艳娇 张宇昕 田佳星[2] WEI Jiahua;FANG Xinyi;MIAO Runyu;ZHANG Yanjiao;ZHANG Yuxin;TIAN Jiaxing(Shunyi Hospital,Beijing Hospital of Traditional Chinese Medicine,Beijing 101399,China;Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]北京中医医院顺义医院,北京101399 [2]中国中医科学院广安门医院,北京100053

出　　处：《辽宁中医药大学学报》2024年第10期118-122,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家中医药多学科交叉创新团队项目(ZYYCXTD-D-202001);首都卫生发展科研专项青年优才项目(CD2020-4-4155);转化医学国家重大科技基础设施(上海)开放课题(TMSK-2021-407);中国中医科学院优秀青年科技人才培养专项(ZZ13-YQ-026);中国中医科学院科技创新工程项目(CI2021A01601)。

摘　　要：糖脂代谢紊乱加速了血管并发症的进展,中药综合调整策略显示出巨大的治疗潜力。然而,中药成分复杂、作用途径多样,严重制约了中药的临床应用及现代化进程。现代组学技术的快速发展为中药治疗糖脂代谢疾病的机制探索创造了有利的条件,使揭示中药治疗糖脂代谢疾病的科学内涵成为可能。近年来研究发现中药可以通过调节肠道菌群、降低炎症因子水平、抑制脂肪生成及脂质累积、减少胰岛β细胞的凋亡、提高胰岛素敏感性、改善胰岛抵抗等多靶点、多途径发挥防治糖脂代谢紊乱的作用。文章通过梳理现代组学技术在中药防治糖脂代谢紊乱机制探索中的应用进展,为精准化、客观化揭示中药防治糖脂代谢紊乱的作用机制提供有益参考,为中药临床应用及开发提供理论支撑。The disorder of glucose and lipid metabolism has accelerated the progression of vascular complications,and the comprehensive adjustment strategy of TCM shows enormous therapeutic potential.However,the complex composition and diverse pathways of action of TCM seriously constrain its clinical application and modernization process.The rapid development of modern omics technology has created favorable conditions for exploring the mechanism of TCM in treating glycolipid metabolism diseases,making it possible to reveal the scientific connotation of TCM in treating glycolipid metabolism diseases.In recent years,research has found that traditional Chinese medicine can regulate gut microbiota,reduce levels of inflammatory factors,inhibit fat generation and lipid accumulation,and reduce pancreatic isletsβMultiple targets and pathways play a role in preventing and treating glucose and lipid metabolism disorders,including cell apoptosis,increased insulin sensitivity,and improved pancreatic resistance.This article reviews the application progress of modern omics technology in exploring the mechanism of TCM in preventing and treating glucose and lipid metabolism disorders,providing useful reference for accurately and objectively revealing the mechanism of TCM in preventing and treating glucose and lipid metabolism disorders,and providing theoretical support for the clinical application and development of TCM.

关 键 词：现代组学技术 糖脂代谢紊乱 机制探索 

分 类 号：R259[医药卫生—中西医结合]