参附注射液调节急危重症患者免疫功能的研究进展  

Research Progress of Shenfu Injection on Regulating Immune Function in Critical Illness Patients

作　　者：冯铠滨 邓海霞[2] 吴鑫宇 江佳铃 刘美婷 万家乐 田甜 FENG Kaibin;DENG Haixia;WU Xinyu;JIANG Jialing;LIU Meiting;WAN Jiale;TIAN Tian(Guangxi University of Chinese Medicine,Nanning 530200,Guangxi,China;The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,Guangxi,China)

机构地区：[1]广西中医药大学,广西南宁530200 [2]广西中医药大学第一附属医院,广西南宁530023

出　　处：《辽宁中医药大学学报》2024年第10期189-195,共7页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：广西自然科学基金面上项目(2021JJA141283)。

摘　　要：急危重症患者的免疫功能是决定患者是否能生存的重要影响因素之一,对于维持机体各细胞组织器官的平衡起到不可或缺的作用,而急危重症患者体内出现的过度免疫应激反应极易导致产生细胞因子风暴,释放炎症因子及炎性介质,导致组织器官的可逆或不可逆性损伤。故除了急危重患者对症治疗基础上,患者免疫功能恢复日渐成为我们的研究重点,期许缓解相应程度的超免疫反应,改善临床症状。而参附注射液对其有独特的治疗优势,可通过多途径、多靶点对疾病进行干预,从而提高机体免疫功能,改善预后,提高存活率。文章从免疫功能方面探讨参附注射液在急危重症患者机体免疫紊乱所发挥的作用方面进行综述,为临床上使用参附注射液干预急危重症疾病的发生发展过程提供更多的理论依据。The immune function of critical illness patients is one of the important factors that determine whether patients can survive,and plays an indispensable role in maintaining the balance of various cells,tissues and organs in the body.However,the excessive immune stress reaction in critical illness patients can easily lead to cytokine storms and release inflammatory factors and inflammatory mediators,resulting in reversible or irreversible damage to tissues and organs.Therefore,in addition to symptomatic treatment of acute and critical patients,the recovery of patients'immune function has increasingly become the focus of our research,hoping to alleviate the corresponding degree of hyperimmune response and improve clinical symptoms.Shenfu Injection has a unique therapeutic advantage,which can intervene the disease through multiple ways and multiple targets,so as to improve the immune function of the body,improve the prognosis and increase the survival rate.In this paper,we reviewed the effects of Shenfu Injection on immune disorders in patients with acute and severe diseases from the aspect of immune function,and provided more theoretical basis for clinical intervention of Shenfu Injection in the occurrence and development of acute and severe diseases.

关 键 词：参附注射液 急危重症 免疫功能 炎症反应 心脏骤停 脓毒症 肺损伤 恶性肿瘤 

分 类 号：R259[医药卫生—中西医结合]