活血化瘀中药治疗前列腺癌的机制及用药研究进展  

Research Progress of Activating Blood and Dissolving Stasis TCM in the Treatment of Prostate Cancer

作　　者：袁见 朱莹杰[1] YUAN Jian;ZHU Yingjie(Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院,上海200032

出　　处：《辽宁中医药大学学报》2024年第10期216-220,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：上海市中医肿瘤临床医学研究中心/上海市科学技术委员会资助项目(21MC1930500)。

摘　　要：前列腺癌是临床常见的男性恶性肿瘤,近年来其发病率呈现逐年上升趋势。前列腺癌在中医学中归属于“淋证”“癃闭”“癥积”等疾病的范畴,其病因病机多为年高肾衰,正气不足,而瘀血痰湿聚积下焦,以本虚标实为特点。辨证分型多以虚实夹杂证为主,其中血瘀证是恶性肿瘤的核心病机和重要特征,在前列腺癌的发生发展中占有重要地位。文章从前列腺癌血瘀证的角度切入,概括活血化瘀类中药单体抗前列腺癌的作用机制,总结近年来活血化瘀类中药的经典方、经验方及中药制剂治疗前列腺癌的研究进展,探讨活血化瘀中药防治前列腺癌的药理作用、抑癌机制和用药安全性,为往后的研究与临床治疗提供一些新的思路。Prostate cancer(PC)stands as the predominant malignancy among males,exhibiting a progressively rising annual incidence rate in recent years.The conventional treatments for PC include surgery,chemoradiotherapy,endocrine therapy and immunotherapy,but resolving complications and side effects during the late period of treatment and improving outcomes has been challenging.Recently,an increasing number of studies have demonstrated that traditional Chinese medicines can alleviate side effects of chemotherapy,ameliorate disease outcomes,prolong survival,and improve quality of life,which showing blood stasis syndrome plays an essential role in the treatment of PC.In this article,the progress in the treatment of PC with traditional Chinese medicine for promoting blood circulation and resolving stasis including compounds,extracts,monomers in recent years,is summarized from the perspective of blood stasis syndrome,and the pharmacological effects,cancer suppression mechanisms and safety of traditional Chinese medicines.The article discusses the cutting-edge advancements in blood-activating and stasis-removing traditional Chinese medicine in the prevention and treatment of PC.This exploration aims to offer novel clinical treatment options for future research.

关 键 词：前列腺癌 肿瘤微环境 血瘀证 活血化瘀类中药 研究进展 

分 类 号：R273[医药卫生—中西医结合]