超极速脉搏波评估单纯高甘油三酯血症患者颈动脉弹性衰退的研究  

Ultrafast pulse wave assesses carotid artery elasticity decline in patients with simple hypertriglyceridemia

作　　者：戴萍 朱正球[1] 高慧[1] 栾云[1] 刘文军[2] 姜学忠[3] 黄辉[1] DAI Ping;ZHU Zhengqiu;GAO Hui;LUAN Yun;LIU Wenjun;JIANG Xuezhong;HUANG Hui(Department of Ultrasound,Jiangsu Provincial Hospital of Traditional Chinese Medicine/Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210029,China;School of Mathematics and Statistics,Nanjing University of Information Science and Technology,Nanjing,Jiangsu 210044,China;Department of Ultrasound Diagnosis,Jiangsu Provincial Organ Hospital,Nanjing,Jiangsu 210024,China)

机构地区：[1]江苏省中医院/南京中医药大学附属医院超声医学科,南京210029 [2]南京信息工程大学数学与统计学院,南京210044 [3]江苏省省级机关医院超声诊断科,南京210024

出　　处：《重庆医学》2024年第18期2766-2770,共5页Chongqing Medical Journal

基　　金：国家自然科学基金项目(12271261);江苏省干部保健项目(BJ21026)。

摘　　要：目的探讨超极速脉搏波(ufPWV)技术在评估单纯高甘油三酯(TG)血症患者(以下称单TG高人群)颈动脉弹性衰退中的应用价值。方法选取2020年1月至2022年3月于江苏省中医院/南京中医药大学附属医院心内科门诊就诊,血脂满足:TG≥1.7 mmol/L且总胆固醇(TC)<5.2 mmol/L、低密度脂蛋白胆固醇(LDL-C)<3.4 mmol/L、高密度脂蛋白胆固醇(HDL-C)>1.0 mmol/L的患者纳入单TG高人群组(n=63);选取同期在江苏省中医院/南京中医药大学附属医院体检中心血脂指标TG、TC、LDL-C、HDL-C均在正常范围内的体检者纳入血脂正常人群组(n=68)。收集所有研究对象的临床资料,利用ufPWV技术检测颈总动脉收缩起始脉搏波速度(PWV-BS)、收缩末期脉搏波速度(PWV-ES)、内-中膜厚度(cIMT)。结果单TG高人群组与血脂正常人群组比较,BMI、收缩压、舒张压、TG、空腹血糖(FBG)、cIMT、PWV-ES值差异均有统计学意义(P<0.05);PWV-BS、PWV-ES、cIMT与年龄均呈正相关,PWV-ES相关性最高(r=0.607,P<0.001),cIMT次之(r=0.590,P<0.001),PWV-BS最低(r=0.325,P<0.001);logistic回归分析显示,PWV-ES可作为单TG高人群颈动脉弹性衰退风险的预测因素,且独立于年龄、性别、BMI、收缩压、舒张压、FBG等因素(OR=1.449,P<0.005)。结论ufPWV技术能够评估单TG高人群的颈动脉弹性衰退现象,PWV-ES增高是该人群颈动脉弹性衰退的独立危险因素。Objective To investigate the application value of ultrafast pulse wave velocity(ufPWV)technique in the assessment of carotid artery elasticity decline in the patients with simple hypertriglyceridemia(TG).Methods The patients visiting the cardiology outpatient department of Jiangsu Provincial Hospital of Traditional Chinese Medicine/Affiliated Hospital of Nanjing University of Chinese Medicine from January 2020 to March 2022 were selected,the serum lipid satisfied:TG≥1.7 mmol/L,moreover total cholesterol(TC)<5.2 mmol/L,low density lipoprotein cholesterol(LDL-C)<3.4 mmol/L and high density lipoprotein cholesterol(HDL-C)>1.0 mmol/L,they were included into the simple high TG group(n=63).Sixty-eight healthy subjects undergoing physical examination in this hospital were selected as the normal blood lipid group and their blood lipid indicators TG,TC,LDL-C and HDL-C all were within the normal range.The clinical data of all subjects were collected.The ufPWV technique was used to detect the common carotid artery pulse wave velocity of beginning systole(PWV-BS),pulse wave velocity of ending systolic(PWV-ES)and carotid intima-media thickness(cIMT).Results The body mass index(BMI),systolic blood pressure,diastolic blood pressure,TG,fasting blood glucose(FBG),cIMT and PWV-ES value had statistical differences between the simple high TG group and normal blood lipid group(P<0.05);PWV-BS,PWV-ES and cIMT were positively correlated with age,and the PWV-ES correlation was the highest(r=0.607,P<0.001),followed by cIMT(r=0.590,P<0.001),and PWV-BS(r=0.325,P<0.001)was the lowest;the Logistic regression analysis showed that PWV-ES could serve as a predictive factor of carotid artery elasticity decline in the population with simple TG,moreover which was independent of the factors such as age,gender,BMI,systolic blood pressure,diastolic blood pressure and FBG(OR=1.449,P<0.005).Conclusion The ufPWV technique could evaluate the decline phenomenon of carotid artery elasticity in the population with simple high TG,and the elevated PWV-ES is a

关 键 词：超极速脉搏波 动脉粥样硬化 颈动脉 弹性衰退 甘油三酯 

分 类 号：R589.2[医药卫生—内分泌]