肝爽颗粒联合异甘草酸镁治疗慢性乙型肝炎患者的效果  

Effects of Ganshuang granules combined with Magnesium isoglycyrrhizinate in treatment of patients with chronic hepatitis B

作　　者：彭丽霞 PENG Lixia(Drug and Equipment Department of Infectious Diseases Hospital of Kaifeng,Kaifeng 475000 Henan,China)

机构地区：[1]开封市传染病医院药械科,河南开封475000

出　　处：《中国民康医学》2024年第19期103-105,109,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察肝爽颗粒联合异甘草酸镁治疗慢性乙型肝炎(CHB)患者的效果。方法:选取2022年2月至2023年4月该院收治的86例CHB患者进行前瞻性研究,按照随机数字表法将其分为研究组和对照组各43例。两组均予以常规治疗,在此基础上,对照组予以异甘草酸镁治疗,研究组在对照组基础上联合肝爽颗粒治疗,两组均治疗6个月。比较两组临床疗效,治疗前后肝功能指标[丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)]、肝纤维化指标[透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原蛋白(PC-Ⅲ)、Ⅳ型胶原蛋白(Ⅳ-C)]、炎性因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)]水平,以及不良反应发生率。结果:研究组治疗总有效率为93.02%(40/43),高于对照组的72.09%(31/43),差异有统计学意义(P<0.05);治疗后,研究组ALT、AST、TBIL水平均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组HA、LN、PC-Ⅲ、Ⅳ-C水平均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组IL-6、CRP水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:肝爽颗粒联合异甘草酸镁治疗CHB患者可提高治疗总有效率,降低肝功能指标、肝纤维化指标和炎性因子水平,效果优于单纯异甘草酸镁治疗。Objective:To observe effects of Ganshuang granules combined with Magnesium isoglycyrrhizinate in treatment of patients with chronic hepatitis B(CHB).Methods:A prospective study was conducted on 86 patients with CHB admitted to the hospital from February 2022 to April 2023.According to the random number table method,they were divided into study group and control group,43 cases in each group.Both groups were given routine treatment.On this basis,the control group was treated with Magnesium isoglycyrrhizinate,while the study group was treated with Ganshuang granules on the basis of that of the control group.Both groups were treated for 6 months.The clinical efficacy,the liver function indexes[alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL)],liver fibrosis indexes[hyaluronic acid(HA),laminin(LN),type III procollagen(PC-III),type IV collagen(IV-C)]and inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6)]level s before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 93.02%(40/43),which was higher than 72.09%(31/43)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of ALT,AST and TBIL in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of HA,LN,PC-III and IV-C in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6 and CRP in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ganshuang granules combined with Magnesium isoglycyrrhizinate in the treatment of the CHB patients can improve the total effective rate

关 键 词：慢性乙型肝炎 肝爽颗粒 异甘草酸镁 肝功能 肝纤维化 炎性因子 不良反应 

分 类 号：R512.6[医药卫生—内科学]