治疗性放射性核素的应用及展望  

Application and Prospect of Therapeutic Radionuclides

作　　者：刘红竹 杨丽萍 郑雨璇 卢畅 张冉[1] 梁雨薇 高旭 张镇江 安明惠 谢晶 宫建[1] LIU Hongzhu;YANG Liping;ZHENG Yuxuan;LU Chang;ZHANG Ran;LIANG Yuwei;GAO Xu;ZHANG Zhenjiang;AN Minghui;XIE Jing;GONG Jian(Research Group of Jian Gong on Pharmacoepidemiology and Clinical Drug Evaluation,Shenyang Pharmaceutical University,Shenyang 110016,China;Clinical Trial Research Center,the First Affiliated Hospital of Bengbu Medical University,Bengbu 233000,China)

机构地区：[1]沈阳药科大学药物流行病与临床药物评价课题组,沈阳110016 [2]蚌埠医科大学第一附属医院临床试验研究中心,蚌埠233000

出　　处：《医药导报》2024年第10期1603-1609,共7页Herald of Medicine

基　　金：沈阳药科大学中青年教师事业发展支持计划立项(ZQN202205)。

摘　　要：放射性核素靶向治疗是一种有效的肿瘤治疗方法,它通过载体或介入技术将药物精准地传递至病灶,并发射出特定的射线能量,以最大限度地减少对健康细胞的破坏,从而实现治疗目标。治疗性放射性核素的类型、放射能量、物理半衰期、制备方法、毒性等因素决定了其在临床上的应用范围。该文综述治疗性放射性核素的特点和临床应用现状,以期为靶向治疗用放射性核素临床应用提供参考。Targeted radiation therapy using radionuclides is a favored approach for treating tumors.This procedure involves the delivery of drugs to the lesion site via carriers or interventional methods,followed by the emission of radiation energy that selectively irradiates the lesion tissue.This approach minimizes damage to normal tissue and achieves the desired therapeutic effect.Factors such as the type of therapeutic radionuclide,radiation energy,physical half-life,method of preparation,and toxicity determine their clinical application.In this paper,the characteristics and clinical application of therapeutic radionuclides were reviewed to providing reference for the clinical application of targeted therapeutic radionuclides.

关 键 词：治疗性放射性核素 α射线药物 β射线药物 

分 类 号：R979.6[医药卫生—药品]