占位效应在脑出血后神经损伤中的作用机制研究进展  

Research progress on the mechanism of mass effect in neural injury after intracerebral hemorrhage

作　　者：宫玉华 唐海芫(综述) 李卉(审校) GONG Yuhua;TANG Haiyuan;LI Hui(School of Smart Health,Chongqing Polytechnic University of Electronic Technology,Chongqing 401331,China)

机构地区：[1]重庆电子科技职业大学智慧健康学院,重庆401331

出　　处：《现代医药卫生》2024年第18期3202-3206,共5页Journal of Modern Medicine & Health

基　　金：重庆市自然科学基金面上项目(CSTB2022NSCQ-MSX1539);重庆市教育委员会科学技术研究计划项目(KJQN202203107)。

摘　　要：脑出血(ICH)是由脑实质内血管破裂引起的重要神经系统疾病,具有较高的致死率和致残率。目前,很多研究聚焦于ICH后的损伤机制与干预策略,但临床上尚缺少有效治疗手段可显著改善患者预后。占位效应是ICH过程中血肿对脑组织的力学挤压,血肿占位效应在神经功能损伤中的重要作用已在临床得到广泛共识。因此,探索占位效应介导ICH后原发性损伤和继发性损伤的机制及途径对临床干预策略的制订具有重要的现实意义。该文将对ICH后占位效应在疾病发生、发展过程中的损伤机制与途径进行综述,旨在为ICH后的干预研究提供参考和理论依据。Intracerebral hemorrhage(ICH)is a critical neurological disease caused by the rupture of blood vessels within the brain parenchyma,with high mortality and morbidity rates.Currently,much research has focused on the injury mechanisms and intervention strategies following ICH,yet clinically effective treatments that significantly improve patient outcomes remain scarce.The mass effect refers to the mechanical compression of brain tissue by the hematoma during ICH,and its crucial role in neural function damage has been widely recognized in clinical practice.Therefore,exploring the mechanisms and pathways of the mass effect mediating primary and secondary injuries after ICH holds significant practical importance for the development of clinical intervention strategies.This article reviews the injury mechanisms and pathways of the mass effect during the onset and progression of ICH,aiming to provide references and theoretical bases for intervention research following ICH.

关 键 词：脑出血 占位效应 神经损伤 机制 综述 

分 类 号：R3[医药卫生—基础医学] R722.151