血清超敏C反应蛋白及D-二聚体联合检测对妊娠高血压综合征的诊断价值研究  

Study on the diagnostic value of combined detection of serum Hcy hs CRP and D-dimer in pregnancy-induced hypertension syndrome

作　　者：王玉锋 Wang Yufeng(Department of Laboratory,Zhengzhou Maternal and Child Health Hospital,Henan 450000,China)

机构地区：[1]河南省郑州市妇幼保健院检验科,450000

出　　处：《山西医药杂志》2024年第16期1235-1238,共4页Shanxi Medical Journal

摘　　要：目的探讨血清超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)、D-二聚体(D-D)联合检测对妊娠高血压综合征的诊断价值。方法选择2022年2月至2023年6月就诊于郑州市妇幼保健院的65例妊娠高血压综合征患者并纳入观察组,65例正常孕妇作为对照组。对比2组孕妇hs-CRP、Hcy、D-D检测值差异,并分析hs-CRP、Hcy、D-D联合检测诊断妊娠高血压综合征价值。结果观察组孕妇hs-CRP检测值为(8.14±2.21)mg/L、Hcy检测值为(13.26±3.20)μmol/L、D-D检测值为(3.24±0.78)mg/L,高于对照组的(3.04±0.78)mg/L、(5.62±1.11)μmol/L、(0.67±0.12)mg/L,差异有统计学意义(P<0.05);hs-CRP、Hcy、D-D联合检测妊娠高血压综合征的灵敏度为97%(63/65)、特异度为94%(61/65)、阴性预测值为97%(62/64)、阳性预测值为95%(63/66)、准确度为96%(125/130),均高于三项指标单一检测,差异有统计学意义(P<0.05)。结论妊娠高血压综合征患者血清hs-CRP、Hcy、D-D水平均异常升高,三者联合检测可提高妊娠高血压综合征检出率,指导临床治疗。Objective To explore the diagnostic value of combined detection of serum hypersensitive C-reactive protein(hs-CRP),homocysteine(Hcy),and D-dimer(D-D)in pregnancy-induced hypertension(PIH).Methods A total of 65 patients with pregnancy-induced hypertension admitted to Zhengzhou Maternal and Child Health Hospital from February 2022 to June 2023 were selected and included in the observation group.Sixty-five normal pregnant women were selected as the control group.hs CRP,Hcy,and D-D were measured.The differences in hs-CRP,Hcy,and D-D detection values between two groups of pregnant women were compared,and the value of hs CRP,Hcy,and D-D combined detection in the diagnosis of pregnancy-induced hypertension syndrome were analyzed.Results The hs CRP detection value of pregnant women in the observation group was(8.14±2.21)mg/L,the Hcy detection value was(13.26±3.20)μmol/L and D-D was(3.24±0.78)mg/L,which were higher than those of the control group(3.04±0.78)mg/L,(5.62±1.11)μmol/L,and(0.63±0.12)mg/L(P<0.05).The sensitivity,specificity,negative predictive value,positive predictive value,and accuracy of the combined detection of hs CRP,Hcy,and D-D for pregnancy-induced hypertension syndrome were 97%(63/65),94%(61/65),97%(62/64),95%(63/66),and 96%(125/130),all higher than those of the single detection of the three indicators,with statistical differences(P<0.05).Conclusion The serum levels of hs-CRP,Hcy,and D-D in patients with pregnancy-induced hypertension are abnormally elevated.Combined detection of the three can improve the detection rate of pregnancy-induced hypertension and guide clinical treatment.

关 键 词：高血压 妊娠性 同型半胱氨酸 D-二聚体 超敏C反应蛋白 诊断 

分 类 号：R714.246[医药卫生—妇产科学] R446.11[医药卫生—临床医学]