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作 者:任智文[1] 王婷[1] 倪小清 REN Zhiwen;WANG Ting;NI Xiaoqing(Department of Pharmacy,Sichuan Academy of Medical Sciences&Sichuan Provincial People′s Hospital,Chengdu 610072,China)
机构地区:[1]四川省医学科学院·四川省人民医院药学部,成都市610072
出 处:《临床合理用药杂志》2024年第27期36-39,共4页Chinese Journal of Clinical Rational Drug Use
基 金:四川省人民医院院级科研基金项目(2023RKX06)。
摘 要:目的分析近年来四川省医学科学院·四川省人民医院住院患者质子泵抑制剂(PPIs)使用情况,为临床PPIs的合理使用提供参考。方法收集医院住院信息管理系统中2019—2023年住院患者使用PPIs相关数据信息,包含药物名称、规格、剂型、使用数量和金额等;依据世界卫生组织推荐的限定日剂量(DDD)、用药数量和金额、用药频度(DDDs)和限定日费用(DDC)等药物经济学指标,对相关数据进行统计分析。结果医院住院患者PPIs的使用量呈逐年下降趋势,且使用金额及金额占比均呈逐年下降趋势,其中雷贝拉唑(口服)、兰索拉唑(口服)与艾司奥美拉唑(注射)分别占据DDDs和使用金额的前3位。用药金额与用药人数同步性呈逐年变好趋势,B/A值为1.00的品种占比从2019年的0升至2021年的25%,再到2023年的75%。结论医院住院患者PPIs使用基本合理,用量较大的雷贝拉唑(口服)、兰索拉唑(口服)和艾司奥美拉唑(注射)是目前抑酸剂的一线用药。Objective To analyze the use of PPIs in inpatients of Sichuan Academy of Medical Sciences and Sichuan Provincial People′s Hospital in recent years,and to provide a reference for the rational use of PPIs in clinical practice.Methods The data related to the use of PPIs by inpatients from 2019 to 2023 in the hospital inpatient information management system were collected,including drug,specification,dosage form,quantity and amount of drugs.According to the pharmacoeconomic indicators recommended by the WHO,such as DDD,quantity and amount of drugs,DDDs and DDC,the relevant data were statistically analyzed.Results The use of PPIs in hospital inpatients showed a decreasing trend year by year,and the amount and proportion of the amount used decreased year by year,among which rabeprazole(oral),lansoprazole(oral)and esomeprazole(injection)accounted for the top three DDDs and the amount of use.The synchronization between the amount of medication and the number of users had been improving year by year,and the proportion of varieties with a B/A value of 1.00 increased from 0 in 2019 to 25%in 2021,and then to 75%in 2023.Conclusion The use of PPIs in hospital patients is basically reasonable,and rabeprazole(oral),lansoprazole(oral)and esomeprazole(injection)are the first-line drugs for antacids.
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