未成熟卵母细胞的体外成熟技术研究进展  

Research progress of immature oocyte in vitro maturation

作　　者：黄芷怡 邓春雷 HUANG Zhiyi;DENG Chunlei(Center of Reproductive Medicine,Taihe Hospital,Affiliated Hospital of Hubei University of Medicine,Shiyan 442000,Hubei Province,China;Hubei Province Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells,Shiyan 442000,Hubei Province,China)

机构地区：[1]十堰市太和医院/湖北医药学院附属医院生殖医学中心,湖北十堰442000 [2]湖北省脐带血造血干细胞治疗临床医学研究中心,湖北十堰442000

出　　处：《医学新知》2024年第9期1049-1056,共8页New Medicine

基　　金：湖北省教育厅重点项目(D20222102);湖北医药学院研究生教育教学项目(YJ2022007);湖北省脐带间充质干细胞治疗临床医学研究中心开放课题(2024SCOF-012)。

摘　　要：随着我国人口出生率显著下降,辅助生殖技术在缓解生育力低下方面的作用日益显著。未成熟卵母细胞体外成熟技术作为辅助生殖技术的一部分,临床应用逐渐增多。本文介绍了未成熟卵母细胞体外成熟技术的发展历史,总结了双相培养体系、培养体系添加剂、3D培养体系等未成熟卵母细胞体外成熟现有培养体系技术,并对未成熟卵母细胞体外成熟培养在多囊卵巢综合征、卵巢抵抗综合征、女性生育力保存、常规取卵过多的补救等方面的临床应用进行概述,以期为未成熟卵母细胞体外成熟培养的相关研究和临床应用提供理论依据。With the significant decline of China's birth rate,the role of assisted reproductive technology in alleviating low fertility is increasingly significant.Immature oocyte in vitro maturation technology,as a part of assisted reproductive technology,is gradually being applied in clinical practice.This article introduced the development history of immature oocyte in vitro maturation technology,summarized the existing culture system technologies for immature oocyte in vitro maturation such as biphasic culture system,culture system additives,3D culture system,and then summarized the clinical applications of immature oocyte in vitro maturation culture in polycystic ovarian syndrome,resistant ovary syndrome,female fertility preservation,and remediation of excessive conventional egg retrieval,to provide theoretical basis for related research and clinical applications of immature oocyte in vitro maturation.

关 键 词：体外成熟 未成熟卵母细胞 辅助生殖技术 多囊卵巢综合征 卵巢抵抗综合征 

分 类 号：R711.6[医药卫生—妇产科学]