去势抵抗性前列腺癌患者血清TRAF6、CGRP水平与骨转移及预后的关系  

The relationship between serum TRAF6,CGRP levels and bone metastasis,prognosis in castration-resistant prostate cancer patients

作　　者：景琼 刘燕南 JING Qiong;LIU Yannan(Urology Department,Qingyang People's Hospital,Gansu Qingyang 745000,China.)

机构地区：[1]庆阳市人民医院泌尿外科,甘肃庆阳745000

出　　处：《现代肿瘤医学》2024年第19期3752-3756,共5页Journal of Modern Oncology

基　　金：甘肃省自然科学基金(编号:20JR5RA0155)。

摘　　要：目的:探讨TNF受体相关因子6(TNF receptor-associated factor 6,TRAF6)、神经元降钙素基因相关肽(neuronal calcitonin gene-related peptide,CGRP)与老年去势抵抗性前列腺癌患者骨转移以及预后的关系分析。方法:选择2020年01月至2023年01月我院收治的157例老年去势抵抗性前列腺癌患者(前列腺癌组)和101例健康志愿者(对照组),根据是否发生骨转移分为骨转移(84例)和非骨转移组(73例)。检测血清TRAF6、CGRP水平,出院后随访去势抵抗性前列腺癌患者生存情况。结果:前列腺癌组血清TRAF6、CGRP水平高于对照组(P<0.01)。Gleason评分≥8分、TNM分期Ⅲc-Ⅳb期去势抵抗性前列腺癌患者血清TRAF6、CGRP水平高于Gleason评分<8分、TNM分期Ⅲa-Ⅲb期期患者(P<0.05)。骨转移组血清TRAF6、CGRP水平高于非骨转移组(P<0.01)。Kaplan-Meier生存分析显示高TRAF6水平组、高CGRP水平组OS生存率低于低RAF6水平组、低CGRP水平组(P<0.05)。多因素COX回归分析结果显示TNM分期Ⅲc-Ⅳb期、骨转移、高水平TRAF6、高水平CGRP是去势抵抗性前列腺癌患者预后的危险因素(P<0.05)。结论:老年前列腺癌患者血清TRAF6、CGRP水平增高与前列腺癌恶性临床病理特征、骨转移和不良预后有关,可作为骨转移和预后评估的标志物。Objective:To investigate the relationship between TNF receptor-associated factor 6(TRAF6),neuronal calcitonin gene-related peptide(CGRP)and bone metastasis and prognosis in elderly castration-resistant prostate cancer patients.Methods:157 patients with castration-resistant prostate cancer(prostate cancer group)and 101 healthy volunteers(control group)admitted to our hospital from January 2020 to January 2023 were selected and divided into bone metastasis group(84 cases)and non-bone metastasis group(73 cases)according to whether bone metastasis occurred.Serum TRAF6 and CGRP levels were detected,and the survival of castration-resistant prostate cancer patients was followed up after discharge.Results:The levels of serum TRAF6 and CGRP in prostate cancer group were higher than those in control group(P<0.01).Serum TRAF6 and CGRP levels in castration-resistant prostate cancer patients with Gleason score≥8 and TNM stageⅢc-Ⅳb were higher than those in Gleason score<8 and TNM stageⅢa-Ⅲb(P<0.05).The levels of serum TRAF6 and CGRP in bone metastasis group were higher than those in non-bone metastasis group(P<0.01).Kaplan-Meier survival analysis showed that the OS survival rate of high TRAF6 and high CGRP groups was lower than that of low RAF6 and low CGRP groups(P<0.05).Multivariate COX regression analysis showed that TNM stageⅢc-Ⅳb,bone metastasis,high TRAF6 level and high CGRP level were the risk factors for prognosis of castration-resistant prostate cancer(P<0.05).Conclusion:The increase of serum TRAF6 and CGRP levels in elderly patients with prostate cancer is related to malignant clinicpathological features,bone metastasis and poor prognosis of prostate cancer,and can be used as markers for bone metastasis and prognosis evaluation.

关 键 词：前列腺癌 骨转移 预后 TNF受体相关因子6 神经元降钙素基因相关肽 

分 类 号：R737.25[医药卫生—肿瘤]